Chu S W, Nesheim M C
J Nutr. 1979 Oct;109(10):1752-8. doi: 10.1093/jn/109.10.1752.
Experiments were carried out to study urea excretion during arginine or ornithine infusion into wing veins of hens previously fed diets that induced different arginase levels in their kidneys. Urea excretion was found to increase as plasma arginine increased. Hens with high levels of arginase activity in their kidneys had a greater increase in urea excretion than hens with low kidney arginase activity. Arginine degradation was also dependent on both the kidney arginase activity and on the plasma level of arginine. Ornithine infusion did not inhibit urea excretion even when high levels of plasma ornithine were reached. Even though ornithine was an in vitro inhibitor of arginase, no evidence was obtained of in vivo inhibition.
进行了实验，以研究在向预先饲喂诱导其肾脏中精氨酸酶水平不同的日粮的母鸡翼静脉输注精氨酸或鸟氨酸期间的尿素排泄情况。发现尿素排泄量随着血浆精氨酸水平的升高而增加。肾脏中精氨酸酶活性高的母鸡，其尿素排泄量的增加幅度大于肾脏中精氨酸酶活性低的母鸡。精氨酸降解也取决于肾脏精氨酸酶活性和血浆精氨酸水平。即使达到高血浆鸟氨酸水平，输注鸟氨酸也不会抑制尿素排泄。尽管鸟氨酸在体外是精氨酸酶的抑制剂，但未获得体内抑制的证据。
