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1
A controlled trial of a protein-free liver extract in the treatment of chronic liver disease.一项关于无蛋白肝提取物治疗慢性肝病的对照试验。
Gut. 1969 Nov;10(11):882-5. doi: 10.1136/gut.10.11.882.
2
Controlled prospective trial of corticosteroid therapy in active chronic hepatitis.皮质类固醇疗法治疗活动性慢性肝炎的对照前瞻性试验
Q J Med. 1971 Apr;40(158):159-85. doi: 10.1093/oxfordjournals.qjmed.a067264.
3
Alcoholic hepatitis. Natural history and evaluation of prednisolone therapy.酒精性肝炎。自然病史及泼尼松龙治疗评估。
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4
Double-blind study of a total liver extract in patients with hepatic dysfunction.肝提取物对肝功能不全患者的双盲研究。
Int J Clin Pharmacol Biopharm. 1975 Apr;11(3):210-5.
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Controlled trial of D-penicillamine with low dosis in the treatment of chronic liver diseases.
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The significance of Mallory bodies in the progression of fatty liver into cirrhosis.马洛里小体在脂肪肝进展为肝硬化过程中的意义。
Acta Pathol Microbiol Scand A. 1974 Jul;82(4):483-6. doi: 10.1111/j.1699-0463.1974.tb00376.x.
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Cas Lek Cesk. 1967 Oct 20;106(43):1143-50.
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Effect of renal and hepatic disease on vitamin-B12 metabolism.肾脏和肝脏疾病对维生素B12代谢的影响。
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Liver function during amantadine hydrochloride medication in compensated liver disease.代偿性肝病患者服用盐酸金刚烷胺期间的肝功能
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本文引用的文献

1
[The treatment of liver parenchyme diseases with a liver total extract].[用肝脏全提取物治疗肝实质疾病]
Wien Klin Wochenschr. 1954 Oct 15;66(41):779-85.
2
[Results of treatment with a protein-free liver extract].[无蛋白肝提取物的治疗结果]
Praxis. 1962 Apr 26;51:444-9.
3
[The action of total liver extracts on the regenerative power of the hepatic parenchyma. Weight and morphological aspects after experimental resection].[全肝提取物对肝实质再生能力的作用。实验性切除后的重量及形态学方面]
Gazz Med Ital. 1962 Apr;121:87-99.
4
Influence of a liver preparation on liver of cats receiving carbon tetrachloride.一种肝脏制剂对接受四氯化碳的猫的肝脏的影响。
Proc Soc Exp Biol Med. 1961 Mar;106:645-8. doi: 10.3181/00379727-106-26429.
5
[Experimental liver cirrhosis due to choline deficiency & its therapeutic control].[胆碱缺乏所致实验性肝硬化及其治疗控制]
Schweiz Med Wochenschr. 1958 Jan 25;88(4):86-9.
6
Determination of sulfobromophthalein in serum.血清中磺溴酞的测定。
Clin Chem. 1957 Oct;3(5):638-45.
7
[Treatment of certain liver disorders with acqueous raw and dealbuminized extracts].[用水溶性粗提物和脱蛋白提取物治疗某些肝脏疾病]
Prog Med (Napoli). 1956 Oct 31;12(20):627-33.
8
[Contribution to the study of the treatment of chronic liver diseases with a total liver extract].[全肝提取物治疗慢性肝病的研究贡献]
Praxis. 1956 Nov 22;45(47):1105-8.
9
[Influence of organ extracts on tissue oxygen consumption].[器官提取物对组织氧消耗的影响]
Experientia. 1956 Nov 15;12(11):433-4. doi: 10.1007/BF02157372.
10
[Treatment of liver diseases with a whole liver extract].[用全肝提取物治疗肝脏疾病]
Acta Gastroenterol Belg. 1955 Jun;18(6):603-19.

一项关于无蛋白肝提取物治疗慢性肝病的对照试验。

A controlled trial of a protein-free liver extract in the treatment of chronic liver disease.

作者信息

Toghill P J, Knill-Jones R P, Williams R

出版信息

Gut. 1969 Nov;10(11):882-5. doi: 10.1136/gut.10.11.882.

DOI:10.1136/gut.10.11.882
PMID:4902196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1553051/
Abstract

A double-blind trial of a protein-free liver extract (Ripason) which was administered both orally and intramuscularly is described in 20 patients with stable cirrhosis. Control and treated groups were similar in composition except for age. Both groups showed some symptomatic improvement during the trial. Fewer patients were recorded as worse on Ripason but no significant changes in body weight, haemoglobin, or liver function tests could be detected.

摘要

对20例稳定期肝硬化患者进行了一项关于无蛋白肝提取物（利帕松）的双盲试验，该提取物通过口服和肌肉注射给药。除年龄外，对照组和治疗组的组成相似。两组在试验期间均有一些症状改善。记录显示使用利帕松后病情恶化的患者较少，但未检测到体重、血红蛋白或肝功能测试有显著变化。