Preziosi P, Nisticò G, Marano V
Int J Clin Pharmacol Biopharm. 1975 Apr;11(3):210-5.
Forty hospitalized male patients with hepatic functional deficit were treated i.m. for 3 weeks with a total liver extract or placebo. The study was a double-blind. Statistical analysis (Student's t test, analysis of variance. Mann-Whitney test and Fisher's probability test) showed that liver extract therapy was more effective than placebo in improving liver function as indicated by changes in clinical features(digestive disorders, constipation, hepatomegaly) and colloidal and other laboratory tests, e.g. plasma cholesterol, prothrombin time, red cell count and hemoglobin concentration. An overall clinical assessment showed that 60% of patients treated with the liver extract were improved. In addition, no local or general side effects were observed. Present results are in favour of an hepatoprotective activity of a total liver extract.
四十名肝功能不全的住院男性患者接受了为期3周的肌肉注射全肝提取物或安慰剂治疗。该研究为双盲试验。统计分析（学生t检验、方差分析、曼-惠特尼检验和费舍尔概率检验）表明，从临床特征（消化系统紊乱、便秘、肝肿大）的变化以及胶体和其他实验室检查（如血浆胆固醇、凝血酶原时间、红细胞计数和血红蛋白浓度）来看，肝提取物疗法在改善肝功能方面比安慰剂更有效。全面的临床评估显示，接受肝提取物治疗的患者中有60%病情有所改善。此外，未观察到局部或全身副作用。目前的结果支持全肝提取物具有肝脏保护活性的观点。
