大肠杆菌突变体中染色体复制的温度敏感起始
Temperature-sensitive initiation of chromosome replication in a mutant of Escherichia coli.
作者信息
Kuempel P L
出版信息
J Bacteriol. 1969 Dec;100(3):1302-10. doi: 10.1128/jb.100.3.1302-1310.1969.
Abstract
The properties of Escherichia coli mutant D2-47LT indicate that it is temperature-sensitive for a protein required for the initiation of chromosome replication. The results of several different experiments are consistent with this hypothesis, and no support was found for the alternate hypotheses tested. Although the strain is usually unable to initiate replication at 42 C, some of the initiation proteins are apparently synthesized at the restrictive temperature. This can cause initiation on partially replicated, but not completed, chromosomes. It appears that the temperature-sensitive protein is required for initiation on completed chromosomes.
摘要
大肠杆菌突变体D2 - 47LT的特性表明，它对染色体复制起始所需的一种蛋白质具有温度敏感性。几个不同实验的结果与这一假设一致，并且未发现对所测试的其他假设的支持。尽管该菌株通常在42℃时无法起始复制，但一些起始蛋白显然在限制温度下合成。这会导致在部分复制但未完成的染色体上起始复制。似乎温度敏感蛋白是在完整染色体上起始复制所必需的。
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