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Evaluation in man of fenclozic acid (I.C.I. 54,450: Myalex), a new anti-inflammatory agent. I. Serum concentration studies in healthy individuals and in patients with rheumatoid arthritis.

作者信息

Chalmers T M, Pohl J E, Platt D S

出版信息

Ann Rheum Dis. 1969 Nov;28(6):590-4. doi: 10.1136/ard.28.6.590.

DOI:10.1136/ard.28.6.590
PMID:4903318
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1031292/
Abstract
摘要

相似文献

1
Evaluation in man of fenclozic acid (I.C.I. 54,450: Myalex), a new anti-inflammatory agent. I. Serum concentration studies in healthy individuals and in patients with rheumatoid arthritis.新型抗炎药氯苯酰酸（I.C.I. 54,450：Myalex）的人体评估。I. 健康个体及类风湿性关节炎患者的血清浓度研究。
Ann Rheum Dis. 1969 Nov;28(6):590-4. doi: 10.1136/ard.28.6.590.
2
Evaluation in man of fenclozic acid (I.C.I. 54,450: Myalex), a new anti-inflamatory agent. II. Clinical trial in patients with rheumatoid arthritis.新型抗炎药芬克洛酸（ICI 54,450：Myalex）的人体评估。II. 类风湿性关节炎患者的临床试验。
Ann Rheum Dis. 1969 Nov;28(6):595-601. doi: 10.1136/ard.28.6.595.
3
Pharmacokinetics of fenclozic acid in animals and man.
J Pharm Sci. 1971 Mar;60(3):366-71. doi: 10.1002/jps.2600600305.
4
[New prospects in antirheumatic therapy. 3. Biometric evaluation of laboratory results in a multicentric research].[抗风湿治疗的新前景。3. 多中心研究中实验室结果的生物统计学评估]
Minerva Med. 1973;64(48):2515-21.
5
Fenclozic acid.芬克洛酸
Lancet. 1970 Mar 28;1(7648):662-3.
6
Clinical experience with Ibuprofen in the treatment of rheumatoid arthritis.布洛芬治疗类风湿性关节炎的临床经验。
Ann Rheum Dis. 1969 Sep;28(5):513-7. doi: 10.1136/ard.28.5.513.
7
The pharmacology of fenclozic acid (2-(4-chlorophenyl)-thiazol-4-ylacetic acid; I.C.I. 54,450; 'Myalex'); a new compound with anti-inflammatory, analgesic and antipyretic activityl.芬氯酸（2-（4-氯苯基）-噻唑-4-乙酸；ICI 54,450；“Myalex”）的药理学：一种具有抗炎、镇痛和解热活性的新化合物。
Br J Pharmacol. 1969 Mar;35(3):487-97. doi: 10.1111/j.1476-5381.1969.tb08290.x.
8
2-(4-chlorophenyl)thiazol-4-ylacetic acid('Myalex'): a new compound with anti-inflammatory,, analgesic and antipyretic activity.
Nature. 1969 Feb 8;221(5180):582-3. doi: 10.1038/221582b0.
9
Serum biochemical values in rheumatoid disease.类风湿病中的血清生化值。
Ann Rheum Dis. 1971 Mar;30(2):166-70. doi: 10.1136/ard.30.2.166.
10
Rheumatoid arthritis in a dog.犬类风湿性关节炎
Cornell Vet. 1975 Jan;65(1):100-11.

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1
The metabolic fate of fenclozic acid in chimeric mice with a humanized liver.具有人源化肝脏的嵌合小鼠中芬氯酸的代谢命运。
Arch Toxicol. 2018 Sep;92(9):2819-2828. doi: 10.1007/s00204-018-2274-0. Epub 2018 Aug 9.
2
Acute liver effects, disposition and metabolic fate of [C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice.对正常和胆管插管的雄性C57BL/6J小鼠口服[C] - 芬克洛酸后的急性肝脏效应、处置及代谢命运
Arch Toxicol. 2017 Jul;91(7):2643-2653. doi: 10.1007/s00204-016-1894-5. Epub 2016 Nov 28.
3
The pharmacokinetics of diclofenac sodium in patients with active rheumatoid disease.双氯芬酸钠在活动性类风湿疾病患者中的药代动力学。
Eur J Clin Pharmacol. 1982;21(4):331-4. doi: 10.1007/BF00637622.
4
Evaluation in man of fenclozic acid (I.C.I. 54,450: Myalex), a new anti-inflamatory agent. II. Clinical trial in patients with rheumatoid arthritis.新型抗炎药芬克洛酸（ICI 54,450：Myalex）的人体评估。II. 类风湿性关节炎患者的临床试验。
Ann Rheum Dis. 1969 Nov;28(6):595-601. doi: 10.1136/ard.28.6.595.
5
Influence of renal failure, rheumatoid arthritis and old age on the pharmacokinetics of diflunisal.肾衰竭、类风湿关节炎及老年对二氟尼柳药代动力学的影响。
Eur J Clin Pharmacol. 1989;36(2):165-74. doi: 10.1007/BF00609190.

本文引用的文献

1
ABNORMALITIES OF SERUM PROTEINS AS CRITERIA FOR THE DIAGNOSIS OF ACUTE RHEUMATIC FEVER.血清蛋白异常作为急性风湿热诊断标准
Am J Med Sci. 1964 Apr;247:431-7. doi: 10.1097/00000441-196404000-00006.
2
CHEMOTHERAPY OF ARTHRITIS INDUCED IN RATS BY MYCOBACTERIAL ADJUVANT.分枝杆菌佐剂诱导大鼠关节炎的化学疗法
Br J Pharmacol Chemother. 1963 Aug;21(1):127-36. doi: 10.1111/j.1476-5381.1963.tb01508.x.
3
Interaction of serum and sodium salicylate: changes during acute infection and its influence on pharmacological activity.血清与水杨酸钠的相互作用：急性感染期间的变化及其对药理活性的影响。
Bull Johns Hopkins Hosp. 1960 Nov;107:278-90.
4
Application of isotope derivative technique to assay of secondary amines: estimation of desipramine by acetylation with H3-acetic anhydride.同位素衍生技术在仲胺测定中的应用：用H3-乙酸酐乙酰化法测定地昔帕明
J Pharmacol Exp Ther. 1967 Sep;157(3):503-8.
5
Rate of accumulation and plateau plasma concentration of drugs after chronic medication.
J Pharm Pharmacol. 1968 May;20(5):390-2. doi: 10.1111/j.2042-7158.1968.tb09766.x.