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芬氯酸（2-（4-氯苯基）-噻唑-4-乙酸；ICI 54,450；“Myalex”）的药理学：一种具有抗炎、镇痛和解热活性的新化合物。

The pharmacology of fenclozic acid (2-(4-chlorophenyl)-thiazol-4-ylacetic acid; I.C.I. 54,450; 'Myalex'); a new compound with anti-inflammatory, analgesic and antipyretic activityl.

作者信息

Newbould B B

出版信息

Br J Pharmacol. 1969 Mar;35(3):487-97. doi: 10.1111/j.1476-5381.1969.tb08290.x.

DOI:10.1111/j.1476-5381.1969.tb08290.x
PMID:5809740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1703354/
Abstract
  1. Fenclozic acid (2-(4-chlorophenyl)thiazol-4-ylacetic acid; I.C.I. 54,450; "Myalex") is one representative of a new class of compounds with antiinflammatory, analgesic and antipyretic properties as evidenced by its activity in a variety of tests in rats, mice and guinea-pigs.2. In tests of short duration the potency of fenclozic acid is similar to that of phenylbutazone.3. In tests of longer duration fenclozic acid is more potent than phenylbutazone.4. The activity of fenclozic acid is not mediated by stimulation of the adrenals and the compound is devoid of corticosteroid-like activity.
摘要

  1. 芬氯酸（2-(4-氯苯基)噻唑-4-乙酸；ICI 54,450；“Myalex”）是一类具有抗炎、镇痛和解热特性的新化合物的代表，这一点已在大鼠、小鼠和豚鼠的各种试验中得到证实。

  2. 在短期试验中，芬氯酸的效力与保泰松相似。

  3. 在长期试验中，芬氯酸比保泰松更有效。

  4. 芬氯酸的活性不是通过刺激肾上腺介导的，且该化合物没有类皮质激素活性。

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Pharmacol Res Commun. 1986 Mar;18(3):241-56. doi: 10.1016/0031-6989(86)90122-0.
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The pharmacology of benoxaprofen (2-[4-chlorophenyl]-alpha-methyl-5-benzoxazole acetic acid), LRCL 3794, a new compound with antiinflammatory activity apparently unrelated to inhibition of prostaglandin synthesis.苯恶洛芬（2-[4-氯苯基]-α-甲基-5-苯并恶唑乙酸），LRCL 3794的药理学，一种具有抗炎活性的新化合物，其抗炎活性显然与抑制前列腺素合成无关。
J Pharm Pharmacol. 1977 Jun;29(6):330-6. doi: 10.1111/j.2042-7158.1977.tb11330.x.
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[Pharmacologic properties of a new, nonsteroidal anti-inflammatory agent, bucloxic acid (804 CB)].一种新型非甾体抗炎药布氯酸（804 CB）的药理特性
Arzneimittelforschung. 1974 Sep;24(9A SUPPL):1368-78.

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Synergistic effect of Kalpaamruthaa on antiarthritic and antiinflammatory properties--its mechanism of action.Kalpaamruthaa在抗关节炎和抗炎特性方面的协同作用——其作用机制。
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Pharmacology of an extract of salai guggal ex-Boswellia serrata, a new non-steroidal anti-inflammatory agent.一种新型非甾体抗炎药——锯叶棕提取物的药理学
Agents Actions. 1986 Jun;18(3-4):407-12. doi: 10.1007/BF01965005.
4
Anti-inflammatory and related properties of 2-(2,4-dichlorophenoxy)phenylacetic acid (fenclofenac).
Agents Actions. 1976 Sep;6(5):657-66. doi: 10.1007/BF01971587.

本文引用的文献

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SUPPRESSION OF ADJUVANT-INDUCED ARTHRITIS IN RATS WITH 2-BUTOXYCARBONYLMETHYLENE-4-OXOTHIAZOLIDINE.2-丁氧羰基亚甲基-4-氧代噻唑烷对大鼠佐剂性关节炎的抑制作用
Br J Pharmacol Chemother. 1965 Jun;24(3):632-40. doi: 10.1111/j.1476-5381.1965.tb01619.x.
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THE USE OF CHANGES IN CAPILLARY PERMEABILITY IN MICE TO DISTINGUISH BETWEEN NARCOTIC AND NONNARCOTIC ALALGESICS.利用小鼠毛细血管通透性的变化来区分麻醉性和非麻醉性镇痛药。
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ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF INDOMETHACIN, 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID.吲哚美辛（1-（对氯苯甲酰基）-5-甲氧基-2-甲基吲哚-3-乙酸）的抗炎和解热活性
J Pharmacol Exp Ther. 1963 Sep;141:369-76.
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Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs.角叉菜胶诱导大鼠后爪水肿作为抗炎药物的一种测定方法。
Proc Soc Exp Biol Med. 1962 Dec;111:544-7. doi: 10.3181/00379727-111-27849.
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A study of pharmacological influences on ultraviolet erythema in guinea pigs.豚鼠紫外线红斑的药理学影响研究。
Arch Int Pharmacodyn Ther. 1958 Sep 1;116(3-4):261-93.
7
Development of arthritis, periarthritis and periostitis in rats given adjuvants.给予佐剂的大鼠关节炎、关节周围炎和骨膜炎的发展。
Proc Soc Exp Biol Med. 1956 Jan;91(1):95-101. doi: 10.3181/00379727-91-22179.
8
The physiological disposition of phenylbutazone (butazolidin) in man and a method for its estimation in biological material.保泰松（布他唑立丁）在人体中的生理处置及其在生物材料中的测定方法。
J Pharmacol Exp Ther. 1953 Nov;109(3):346-57.
9
A new type of cytotoxic immunosuppressive agent: 3-acetyl-5-(4-fluorbenzylidiene)4-hydroxy-2-oxo-2:5-dihydrothiophen.一种新型细胞毒性免疫抑制剂：3-乙酰基-5-（4-氟亚苄基）-4-羟基-2-氧代-2,5-二氢噻吩
Nature. 1966 May 7;210(5036):638-9. doi: 10.1038/210638a0.
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Immunosuppressive activity of 3-acetyl-5-(4-fluorobenzylidene)-4-hydroxy-2-oxo-2:5-dihydrothiophen (I.C.I. 47,776).3-乙酰基-5-（4-氟亚苄基）-4-羟基-2-氧代-2,5-二氢噻吩（ICI 47,776）的免疫抑制活性
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