芬氯酸（2-（4-氯苯基）-噻唑-4-乙酸；ICI 54,450；“Myalex”）的药理学：一种具有抗炎、镇痛和解热活性的新化合物。
The pharmacology of fenclozic acid (2-(4-chlorophenyl)-thiazol-4-ylacetic acid; I.C.I. 54,450; 'Myalex'); a new compound with anti-inflammatory, analgesic and antipyretic activityl.
作者信息
Newbould B B
出版信息
Br J Pharmacol. 1969 Mar;35(3):487-97. doi: 10.1111/j.1476-5381.1969.tb08290.x.
Abstract
- Fenclozic acid (2-(4-chlorophenyl)thiazol-4-ylacetic acid; I.C.I. 54,450; "Myalex") is one representative of a new class of compounds with antiinflammatory, analgesic and antipyretic properties as evidenced by its activity in a variety of tests in rats, mice and guinea-pigs.2. In tests of short duration the potency of fenclozic acid is similar to that of phenylbutazone.3. In tests of longer duration fenclozic acid is more potent than phenylbutazone.4. The activity of fenclozic acid is not mediated by stimulation of the adrenals and the compound is devoid of corticosteroid-like activity.
摘要
芬氯酸（2-(4-氯苯基)噻唑-4-乙酸；ICI 54,450；“Myalex”）是一类具有抗炎、镇痛和解热特性的新化合物的代表，这一点已在大鼠、小鼠和豚鼠的各种试验中得到证实。
在短期试验中，芬氯酸的效力与保泰松相似。
在长期试验中，芬氯酸比保泰松更有效。
芬氯酸的活性不是通过刺激肾上腺介导的，且该化合物没有类皮质激素活性。
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2
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3
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