Hart A, Cohen H
Br Med J. 1970 Jan 3;1(5687):22-4. doi: 10.1136/bmj.1.5687.22.
The effect of 50 mg. of sustained release phenformin capsules administered twice daily was compared with a placebo as an aid to weight reduction in obese non-diabetic patients. Phenformin and placebo were administered alternately in two three-month periods.Weight loss on a 1,200-calorie diet was greater in the first three months than in the second three months regardless of treatment. There was no difference in weight loss between the phenformin and placebo groups in either the first or second three-month period. Serum cholesterol levels tended to fall in association with weight loss, but not apparently in relation to the size of the weight loss or to the treatment.
将每日两次服用50毫克缓释苯乙双胍胶囊的效果与安慰剂进行比较，以帮助肥胖非糖尿病患者减轻体重。在两个三个月的时间段内交替服用苯乙双胍和安慰剂。无论接受何种治疗，在1200卡路里饮食的情况下，前三个月的体重减轻幅度都大于后三个月。在第一个或第二个三个月期间，苯乙双胍组和安慰剂组的体重减轻没有差异。血清胆固醇水平往往随着体重减轻而下降，但显然与体重减轻的幅度或治疗无关。
