苯乙双胍诱导正常受试者发生低血糖症。
Phenformin-induced hypoglycaemia in normal subjects.
作者信息
Lyngsoe J, Trap-Jensen J
出版信息
Br Med J. 1969 Apr 26;2(5651):224-6. doi: 10.1136/bmj.2.5651.224.
Abstract
Study of the effect of phenformin on the blood glucose level in normal subjects before and during 70 hours of starvation showed a statistically significant hypoglycaemic effect after 40 hours of starvation. This effect was not due to increased glucose utilization.Another finding in this study was a statistically significant decrease in total urinary nitrogen excretion during starvation in subjects given phenformin. These findings show that the hypoglycaemic effect of phenformin in starved normal subjects is due to inhibition of gluconeogenesis.
摘要
对正常受试者在饥饿70小时前及期间服用苯乙双胍对血糖水平影响的研究表明，饥饿40小时后出现了具有统计学意义的降血糖作用。这种作用并非由于葡萄糖利用增加所致。该研究的另一项发现是，服用苯乙双胍的受试者在饥饿期间尿总氮排泄量出现了具有统计学意义的下降。这些发现表明，苯乙双胍在饥饿的正常受试者中的降血糖作用是由于抑制糖异生作用。
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