Silvers W K, Lubaroff D M, Wilson D B, Fox D
Science. 1970 Feb 27;167(3922):1264-6. doi: 10.1126/science.167.3922.1264.
The induction of tolerance of Lewis histocompatibility antigens in BN rats inoculated at birth with BNI Lewis F(1) hybrid bone marrow cells, as revealed by the prolonged survival of Lewis skin grafts, is accompanied by markedly decreased reactivity in the mixed lymphocyte interaction. Blood lymphocytes from animals inoculated with lymph node cell suspensions also display diminished proliferative reactivity to hybrid BN/Lewis cells in the interaction. However, these recipients are not tolerant of Lewis skin grafts. Blood lymphocytes from BN rats inoculated neonatally with Lewis thymocytes fail to display any level of unresponsiveness in vitro, and such animals are not tolerant of Lewis skin grafts. The results suggest that in rats skin and marrow cells have histocompatibility antigens that are absent or poorly expressed on lymph node cells and thymocytes.
出生时接种BNI Lewis F(1) 杂交骨髓细胞的BN大鼠对Lewis组织相容性抗原的耐受性诱导，如Lewis皮肤移植物的长期存活所示，伴随着混合淋巴细胞相互作用中反应性的显著降低。接种淋巴结细胞悬液的动物的血液淋巴细胞在相互作用中对杂交BN/Lewis细胞的增殖反应性也降低。然而，这些受体并不耐受Lewis皮肤移植物。新生期接种Lewis胸腺细胞的BN大鼠的血液淋巴细胞在体外未表现出任何无反应水平，且此类动物不耐受Lewis皮肤移植物。结果表明，在大鼠中，皮肤和骨髓细胞具有组织相容性抗原，而这些抗原在淋巴结细胞和胸腺细胞上不存在或表达不佳。
