Desquenne-Clark L, Kimura H, Naji L, Silvers W K
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104.
Transplantation. 1993 Nov;56(5):1230-3. doi: 10.1097/00007890-199311000-00034.
A comparison has been made of the abilities of bone marrow cells and lymph node cells to induce tolerance of skin when inoculated into neonatal rats known to differ only with regard to non-MHC incompatibilities, including putative skin-specific (Skn) antigens. Each recipient received 50 x 10(6) cells, and tolerance was confirmed by the permanent acceptance of donor-strain neonatal heart tissue transplanted to the pinna of the ear. In 5 of the 8 MHC-compatible strain combinations tested, BMC were significantly more effective than LNC in inducing tolerance of skin, whereas in one situation LNC proved more efficient. Although the results are in accord with the occurrence of Skn antigens in rats, it appears that at least some of the antigens involved must also be expressed by BMC or LNC, but not equally by both of these tissues. The results also provide evidence that in rats, as in mice, the MHC can play a major role in determining the response to, and/or the immunogenicity of, Skn antigens.
已对骨髓细胞和淋巴结细胞接种到仅在非主要组织相容性复合体（MHC）不相容性方面存在差异（包括假定的皮肤特异性（Skn）抗原）的新生大鼠体内时诱导皮肤耐受的能力进行了比较。每个受体接受50×10⁶个细胞，并通过永久接受移植到耳廓的供体品系新生心脏组织来确认耐受。在测试的8种MHC相容品系组合中的5种中，骨髓细胞在诱导皮肤耐受方面比淋巴结细胞显著更有效，而在一种情况下淋巴结细胞证明更有效。尽管结果与大鼠中存在Skn抗原一致，但似乎至少一些相关抗原也必须由骨髓细胞或淋巴结细胞表达，但这两种组织的表达并不相同。结果还提供了证据，表明在大鼠中，如同在小鼠中一样，MHC在决定对Skn抗原的反应和/或免疫原性方面可发挥主要作用。
