Gottlieb N L, Page W F, Appelrouth D J, Palmer R, Kiem I M
J Rheumatol. 1979 May-Jun;6(3):316-23.
The prevalence of tonsillectomy and appendectomy was higher in 196 patients with rheumatoid arthritis (RA), prior to the onset of articular disease, than in their spouses and siblings. The estimated increased risk of developing RA with tonsillectomy was 1.5 and 3.5 times, with appendectomy 1.7 and 6.6 times, and with both surgical procedures 2.3 and 6.7 times, using patient-spouse and patient-sibling matched-pair data, respectively. However, only with patient-sibling data did the lower limits of the 95% confidence interval for the risk ratio exceed 1.0. Several hypotheses are offered to explain the possible association between these surgical procedures and RA.
196例类风湿关节炎（RA）患者在关节疾病发作前进行扁桃体切除术和阑尾切除术的比例高于其配偶和兄弟姐妹。利用患者-配偶和患者-兄弟姐妹匹配对数据估计，扁桃体切除术后患RA的风险增加1.5倍和3.5倍，阑尾切除术后增加1.7倍和6.6倍，两种手术均进行后增加2.3倍和6.7倍。然而，仅在患者-兄弟姐妹数据中，风险比的95%置信区间下限超过1.0。文中提出了几种假设来解释这些手术与RA之间可能存在的关联。
