Moens H B, Corstjens A, Boon C
Jan van Breemen Institute, Amsterdam, The Netherlands.
Clin Rheumatol. 1994 Sep;13(3):483-6. doi: 10.1007/BF02242947.
To re-evaluate a reported association of rheumatoid arthritis (RA) with antecendent tonsillectomy or appendectomy, questionnaires were sent by post to 3673 patients who had been diagnosed as having either RA or osteoarthrosis (OA). Of those who responded 1524 were RA and 1194 OA patients. No significant differences were found between these groups with regard to the frequency of prior lymphoid surgery. This was also the case when the RA group was replaced by its rheumatoid factor (Rf) positive or Rf negative subgroup. A separate analysis of a subgroup consisting of 671 Rf positive RA patients for whom OA control subjects matched for sex and year of birth were available again showed no statistical differences in frequencies of tonsillectomy and appendectomy. Neither did partitioning the group according to the age at which lymphoid surgery was performed bring any association with an increased occurrence of RA to light. We therefore reject the hypothesis that RA is associated with antecedent tonsillectomy or appendectomy.
为了重新评估所报道的类风湿关节炎（RA）与既往扁桃体切除术或阑尾切除术之间的关联，我们通过邮寄问卷的方式，向3673名被诊断患有RA或骨关节炎（OA）的患者进行了调查。在回复问卷的患者中，有1524名RA患者和1194名OA患者。在既往淋巴手术的频率方面，这些组之间未发现显著差异。当RA组被其类风湿因子（Rf）阳性或Rf阴性亚组取代时，情况也是如此。对由671名Rf阳性RA患者组成的一个亚组进行单独分析，该亚组有与之匹配性别和出生年份的OA对照受试者，结果再次显示扁桃体切除术和阑尾切除术的频率无统计学差异。根据进行淋巴手术的年龄对该组进行划分，也未发现与RA发生率增加存在任何关联。因此，我们拒绝RA与既往扁桃体切除术或阑尾切除术有关联这一假设。
