金刚烷硫脲衍生物作为抗病毒剂。
Adamantylthiourea derivatives as antiviral agents.
作者信息
Tilley J W, Levitan P, Kramer M J
出版信息
J Med Chem. 1979 Aug;22(8):1009-10. doi: 10.1021/jm00194a025.
PMID:490532
Abstract
A series of nine 3-substituted 1-adamantylthioureas was prepared and tested for antiviral activity against influenza A2/Asian/J305 virus in vivo and in vitro. Protective dose 50 values were calculated for three of the compounds. One of these compounds, 7, has antiviral activity which compares favorably with that of amantadine.
摘要
制备了一系列9种3-取代的1-金刚烷基硫脲，并对其进行了抗甲型流感病毒A2/亚洲/J305株的体内和体外抗病毒活性测试。计算了其中3种化合物的半数保护剂量值。其中一种化合物7具有与金刚烷胺相当的抗病毒活性。
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