特纳综合征患者中慢性炎症性肠病的高发病率。
A high incidence of chronic inflammatory bowel disease in patients with Turner's syndrome.
作者信息
Price W H
出版信息
J Med Genet. 1979 Aug;16(4):263-6. doi: 10.1136/jmg.16.4.263.
Abstract
Four new cases of chronic inflammatory bowel disease in a series of 135 adult patients with Turner's syndrome observed over an average period of 11 years are reported. The diagnosis in 2 of the patients was ulcerative colitis; the other 2 had clinical and histological features consistent with a diagnosis of Crohn's disease. The incidence is considerably higher than any reported frequency of new cases of inflammatory bowel disease in the general population. Previously reported cases are described and attention is drawn to the severity of the bowel disorder. An apparent association with a karyotype abnormality which includes a structurally abnormal X chromosome is noted.
摘要
报告了在135例成年特纳综合征患者中观察到的4例新的慢性炎症性肠病病例，观察期平均为11年。其中2例患者的诊断为溃疡性结肠炎；另外2例具有与克罗恩病诊断相符的临床和组织学特征。其发病率远高于普通人群中炎症性肠病新病例的任何报告频率。对先前报告的病例进行了描述，并提请注意肠道疾病的严重性。注意到与包括结构异常X染色体在内的核型异常存在明显关联。
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