胸腺衍生淋巴细胞对免疫球蛋白独特型的识别。
Recognition of immunoglobulin idiotypes by thymus-derived lymphocytes.
作者信息
Janeway C A, Sakato N, Eisen H N
出版信息
Proc Natl Acad Sci U S A. 1975 Jun;72(6):2357-60. doi: 10.1073/pnas.72.6.2357.
Abstract
The ability of thymus-derived lymphocytes (T cells) from BALB/c mice to recognize the individually specific antigenic determinants (idiotypes) of BALB/c myeloma proteins was tested. Spleen cells from donor mice immunized with a given myeloma protein greatly augmented the response of hapten-specific bone marrow-derived, thymus-independent lymphocytes (cells) to a hapten conjugate of the immunizing myeloma protein. This helper effect was specific for the myeloma protein idiotype; responses to hapten conjugates of similar myeloma proteins, bearing different idiotypic determinants, were not augmented by these spleen cells. That the helper cell is a T cell was shown by its marked sensitivity to cytolysis with an isoantiserum specific for T cells (anti-Thy-1-2) and complement. The discrimination between idiotypes by such T cells is roughly comparable to that of the antibody produced by the donors of the helper cells.
摘要
对来自BALB/c小鼠的胸腺衍生淋巴细胞（T细胞）识别BALB/c骨髓瘤蛋白的个体特异性抗原决定簇（独特型）的能力进行了测试。用给定骨髓瘤蛋白免疫的供体小鼠的脾细胞极大地增强了半抗原特异性骨髓衍生的、不依赖胸腺的淋巴细胞对免疫骨髓瘤蛋白的半抗原偶联物的反应。这种辅助效应对于骨髓瘤蛋白独特型具有特异性；对带有不同独特型决定簇的类似骨髓瘤蛋白的半抗原偶联物的反应，不会被这些脾细胞增强。辅助细胞是T细胞这一点通过其对用T细胞特异性同种抗血清（抗Thy-1-2）和补体进行细胞溶解的显著敏感性得以证明。此类T细胞对独特型的区分与辅助细胞供体产生的抗体的区分大致相当。
相似文献
1
Recognition of immunoglobulin idiotypes by thymus-derived lymphocytes.胸腺衍生淋巴细胞对免疫球蛋白独特型的识别。
Proc Natl Acad Sci U S A. 1975 Jun;72(6):2357-60. doi: 10.1073/pnas.72.6.2357.
2
The role of thymus-derived lymphocytes in an antibody-mediated hapten-specific helper effect.胸腺来源淋巴细胞在抗体介导的半抗原特异性辅助效应中的作用。
Eur J Immunol. 1975 Jan;5(1):17-22. doi: 10.1002/eji.1830050105.
3
Cell co-operation and hapten--carrier complexes.细胞合作与半抗原-载体复合物
Immunology. 1975 Oct;29(4):675-85.
4
The immune response against hapten-autologous protein conjugates in the mouse.小鼠对半抗原-自身蛋白偶联物的免疫反应。
J Exp Med. 1973 Apr 1;137(4):911-31. doi: 10.1084/jem.137.4.911.
5
Idiotype-anti-idiotype network. II. Activation of silent clones by treatment at birth with idiotypes is associated with the expansion of idiotype-specific helper T cells.独特型-抗独特型网络。II. 出生时用独特型进行治疗激活沉默克隆与独特型特异性辅助性T细胞的扩增相关。
J Exp Med. 1982 Aug 1;156(2):506-21. doi: 10.1084/jem.156.2.506.
6
Regulation of myeloma growth in vitro by idiotype-specific T lymphocytes.独特型特异性T淋巴细胞对骨髓瘤体外生长的调节
J Immunol. 1980 Jan;124(1):424-30.
7
8
Enrichment of hapten-specific helper T cells using anti-immunoglobulin combining site antibodies.使用抗免疫球蛋白结合位点抗体富集半抗原特异性辅助性T细胞。
Eur J Immunol. 1980 Feb;10(2):112-6. doi: 10.1002/eji.1830100208.
9
Critical role of determinant presentation in the induction of specific responses in immunocompetent lymphocytes.决定簇呈现在免疫活性淋巴细胞特异性反应诱导中的关键作用。
J Exp Med. 1973 Apr 1;137(4):967-90. doi: 10.1084/jem.137.4.967.
10
Cellular basis of regulation of expression of idiotype. II. Immunity to anti-MOPC-460 idiotype antibodies increases the level of anti-trinitrophenyl antibodies bearing 460 idiotypes.独特型表达调控的细胞基础。II. 对抗MOPC - 460独特型抗体的免疫反应可提高带有460独特型的抗三硝基苯抗体的水平。
J Exp Med. 1979 Apr 1;149(4):815-23. doi: 10.1084/jem.149.4.815.
引用本文的文献
1
Idiotype/anti-idiotype antibodies: as a glorious savior in COVID-19 pandemics.独特型/抗独特型抗体：作为新冠疫情中的光荣救星。
Transl Med Commun. 2021;6(1):18. doi: 10.1186/s41231-021-00097-y. Epub 2021 Aug 23.
2
Lymphoma Immunotherapy: Current Status.淋巴瘤免疫疗法：现状
Front Immunol. 2015 Sep 1;6:448. doi: 10.3389/fimmu.2015.00448. eCollection 2015.
3
Targeted DNA vaccines for enhanced induction of idiotype-specific B and T cells.针对独特型特异性 B 和 T 细胞的靶向 DNA 疫苗。
Front Oncol. 2012 Oct 30;2:154. doi: 10.3389/fonc.2012.00154. eCollection 2012.
4
Active immunotherapy: current state of the art in vaccine approaches for NHL.主动免疫疗法： NHL 疫苗方法的最新进展。
Curr Oncol Rep. 2012 Oct;14(5):433-40. doi: 10.1007/s11912-012-0255-7.
5
Protective role of anti-idiotypic antibodies in autoimmunity--lessons for type 1 diabetes.抗独特型抗体在自身免疫中的保护作用——对 1 型糖尿病的启示。
Autoimmunity. 2012 Jun;45(4):320-31. doi: 10.3109/08916934.2012.659299. Epub 2012 Feb 23.
6
Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells.髓源性抑制细胞通过扩增调节性T细胞促进B细胞淋巴瘤的交叉耐受。
Cancer Res. 2008 Jul 1;68(13):5439-49. doi: 10.1158/0008-5472.CAN-07-6621.
7
Identification of HLA-A2 restricted T-cell epitopes within the conserved region of the immunoglobulin G heavy-chain in patients with multiple myeloma.多发性骨髓瘤患者免疫球蛋白G重链保守区域内HLA - A2限制性T细胞表位的鉴定
Eur J Haematol. 2008 Jul;81(1):26-35. doi: 10.1111/j.1600-0609.2008.01076.x. Epub 2008 Mar 19.
8
Cytotoxic T cells generated against heteroclitic peptides kill primary tumor cells independent of the binding affinity of the native tumor antigen peptide.针对异种特异性肽产生的细胞毒性T细胞可杀死原发性肿瘤细胞，而与天然肿瘤抗原肽的结合亲和力无关。
Blood. 2006 Dec 1;108(12):3865-70. doi: 10.1182/blood-2006-04-014415. Epub 2006 Aug 10.
9
Induction of anti B-cell malignance CTL response by subfamily-shared peptides derived from variable domain of immunoglobulin heavy chain.由免疫球蛋白重链可变区衍生的亚家族共享肽诱导抗B细胞恶性肿瘤CTL反应
Cancer Immunol Immunother. 2005 Nov;54(11):1106-14. doi: 10.1007/s00262-005-0696-z. Epub 2005 May 12.
10
In vitro dendritic cell generation and lymphocyte subsets in myeloma patients: influence of thalidomide and high-dose chemotherapy treatment.骨髓瘤患者的体外树突状细胞生成及淋巴细胞亚群：沙利度胺和大剂量化疗的影响
Cancer Immunol Immunother. 2005 May;54(5):506-12. doi: 10.1007/s00262-004-0633-6. Epub 2004 Nov 20.
本文引用的文献
1
Mouse thymic iso-antigens.小鼠胸腺同种抗原。
Nature. 1966 Jan 29;209(5022):521-3. doi: 10.1038/209521b0.
2
Determination of antibody-hapten equilibrium constants by an ammonium sulfate precipitation technique.用硫酸铵沉淀技术测定抗体-半抗原平衡常数。
J Immunol. 1969 Sep;103(3):625-7.
3
Idiotypic identity of antibodies to streptococcal carbohydrate in inbred mice.近交系小鼠中抗链球菌碳水化合物抗体的独特型同一性
Eur J Immunol. 1972 Aug;2(4):301-7. doi: 10.1002/eji.1830020402.
4
Affinity labeling of a phosphorylcholine binding mouse myeloma protein.磷酸胆碱结合小鼠骨髓瘤蛋白的亲和标记
Biochemistry. 1972 Feb 29;11(5):766-71. doi: 10.1021/bi00755a014.
5
Hapten-specific augmentation of the anti-idiotype antibody response to hapten-myeloma protein conjugates in mice.半抗原特异性增强小鼠对半抗原-骨髓瘤蛋白缀合物的抗独特型抗体反应。
Eur J Immunol. 1973 Jun;3(6):340-7. doi: 10.1002/eji.1830030605.
6
The mechanism of a hapten-specific helper effect in mice.小鼠中半抗原特异性辅助效应的机制。
J Immunol. 1973 Oct;111(4):1250-6.
7
T cell control of antibody production.T细胞对抗体产生的控制。
Contemp Top Immunobiol. 1974;3:1-40. doi: 10.1007/978-1-4684-3045-5_1.
8
9
Immunological paralysis induced by an idiotypic antigen.独特型抗原诱导的免疫麻痹
Nature. 1970 Jul 18;227(5255):274-6. doi: 10.1038/227274a0.
10
Regulation of immune response by autogenous antibody against receptor.自身抗受体抗体对免疫反应的调节
Proc Natl Acad Sci U S A. 1974 Dec;71(12):5083-7. doi: 10.1073/pnas.71.12.5083.
Zotero 插件