Newmark H L, Scheiner J M, Marcus M, Prabhudesai M
JAMA. 1979 Nov 23;242(21):2319-20.
Using extraction procedures in which the extracted vitamin B12 was protected by cyanide or metabisulfite, several investigators found no change in vitamin B12 when meals were incubated in the presence of ascorbic acid for 30 minutes at 37 degrees C. A previous report suggested degradation of vitamin B12 under these conditions, but this was apparently caused by incomplete protection of the extracted vitamin B12 in the assay procedure. If incubation at 37 degrees C for 30 minutes is a laboratory mimic of the gastric environment, one must conclude that high doses of ascorbic acid do not affect the stability of vitamin B12 in vivo.
在使用氰化物或偏亚硫酸氢盐保护提取出的维生素B12的提取程序中，几位研究人员发现，当膳食在37摄氏度下与抗坏血酸一起孵育30分钟时，维生素B12没有变化。之前的一份报告表明在这些条件下维生素B12会降解，但这显然是由于分析程序中提取出的维生素B12保护不完全所致。如果37摄氏度下孵育30分钟是对胃环境的实验室模拟，那么人们必须得出结论，高剂量的抗坏血酸不会影响体内维生素B12的稳定性。
