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通过体内给予胰岛素，肝脏染色质的模板活性增加。

Template activity of liver chromatin increased by in vivo administration of insulin.

作者信息

Morgan C R, Bonner J

出版信息

Proc Natl Acad Sci U S A. 1970 Apr;65(4):1077-80. doi: 10.1073/pnas.65.4.1077.

DOI:10.1073/pnas.65.4.1077
PMID:4909468
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC283025/
Abstract

The hypothesis that insulin may serve as a derepressor of genetic information in the liver of diabetic rats has been tested by comparing the template activity for RNA synthesis of chromatin from liver of insulin-treated diabetic rats to that of chromatin from liver of insulin-deficient diabetic rats. The template activity of the chromatins of insulin-treated diabetic rats is found to be 28 per cent greater than that of chromatin from liver of diabetic rats not treated with insulin. Time course studies show that the template activity of liver chromatin of rats injected with a single dose of insulin reaches a peak at two hours, which is some hours before the appearance of a typical insulin-induced liver enzyme, glucokinase. We conclude that insulin derepresses genetic material of the diabetic liver genome that is repressed in the absence of insulin.

摘要

通过比较胰岛素治疗的糖尿病大鼠肝脏染色质的RNA合成模板活性与胰岛素缺乏的糖尿病大鼠肝脏染色质的模板活性，对胰岛素可能作为糖尿病大鼠肝脏遗传信息去阻遏物的假说进行了检验。发现胰岛素治疗的糖尿病大鼠染色质的模板活性比未用胰岛素治疗的糖尿病大鼠肝脏染色质的模板活性高28%。时间进程研究表明，单次注射胰岛素的大鼠肝脏染色质的模板活性在两小时达到峰值，这比典型的胰岛素诱导肝酶葡萄糖激酶出现要早几个小时。我们得出结论，胰岛素使糖尿病肝脏基因组中在无胰岛素时被阻遏的遗传物质去阻遏。

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Template activity of liver chromatin increased by in vivo administration of insulin.通过体内给予胰岛素，肝脏染色质的模板活性增加。
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本文引用的文献

1
INSULIN-DEPENDENT SYNTHESIS OF LIVER GLUCOKINASE IN THE RAT.大鼠肝脏葡萄糖激酶的胰岛素依赖性合成
J Biol Chem. 1963 Nov;238:3535-8.
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Deoxyribo ucleic acid-directed synthesis of ribonucleic acid by an enzyme from Escherichia coli.大肠杆菌中一种酶催化的脱氧核糖核酸指导的核糖核酸合成。
Proc Natl Acad Sci U S A. 1962 Jan 15;48(1):81-94. doi: 10.1073/pnas.48.1.81.
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Some properties of a nuclear binding site of estradiol.雌二醇核结合位点的一些特性。
J Mol Biol. 1967 Aug 14;27(3):431-41. doi: 10.1016/0022-2836(67)90049-6.
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Template properties of liver chromatin.肝脏染色质的模板特性
J Mol Biol. 1966 Jan;15(1):160-74. doi: 10.1016/s0022-2836(66)80218-8.
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Immunoassay of pancreatic and plasma insulin following alloxan injection of rats.大鼠注射四氧嘧啶后胰腺及血浆胰岛素的免疫测定
Diabetes. 1965 Oct;14(10):669-71. doi: 10.2337/diab.14.10.669.
6
Insulin and the regulation of hepatic biosynthetic activity.胰岛素与肝脏生物合成活性的调节
Vitam Horm. 1966;24:1-61. doi: 10.1016/s0083-6729(08)60202-2.
7
A protein intermediary in the interaction of a hormone with the genome.一种在激素与基因组相互作用中起中介作用的蛋白质。
Proc Natl Acad Sci U S A. 1969 Jul;63(3):897-903. doi: 10.1073/pnas.63.3.897.
8
The statistical analysis of enzyme kinetic data.酶动力学数据的统计分析。
Adv Enzymol Relat Areas Mol Biol. 1967;29:1-32. doi: 10.1002/9780470122747.ch1.
9
Increased template activity of liver chromatin, a result of hydrocortisone administration.氢化可的松给药导致肝脏染色质模板活性增加。
Proc Natl Acad Sci U S A. 1965 Nov;54(5):1370-5. doi: 10.1073/pnas.54.5.1370.

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