Amure B O
Gut. 1970 Feb;11(2):171-5. doi: 10.1136/gut.11.2.171.
This study confirms the preliminary reports that Duogastrone effectively controls the symptoms of duodenal ulceration and appears to hasten healing. In a double-blind trial, 14 patients with active duodenal ulcers were treated with Duogastrone capsules, one four times daily, half-an-hour before meals, while a comparable control group of 14 patients was treated similarly with a placebo containing magnesium trisilicate. Treatment continued for 12 weeks with clinical assessments fortnightly and a radiological assessment at the start and at the end of treatment. Only one of the 14 patients receiving Duogastrone did not respond. The remaining 13 showed marked clinical improvement with complete relief of pain and ceased to require supplementary antacids. Radiological evidence of healing or marked improvement was seen in eight of the 14 patients. None of the patients in the control group showed any marked improvement either of pain or tenderness and no changes were detectable by radiology. Patients in this group showed no reduction in their demand for supplementary antacids to relieve symptoms. No significant side effects were encountered. It is concluded that Duogastrone accelerates the healing of duodenal ulcer in ambulant patients and affords a much greater and more rapid relief of symptoms than does magnesium trisilicate.
本研究证实了初步报告，即多贝斯有效控制十二指肠溃疡症状，且似乎能加速溃疡愈合。在一项双盲试验中，14例活动性十二指肠溃疡患者接受多贝斯胶囊治疗，每日4次，每次1粒，于饭前半小时服用，而另一组由14例患者组成的可比对照组则用含三硅酸镁的安慰剂进行类似治疗。治疗持续12周，每两周进行一次临床评估，并在治疗开始和结束时进行放射学评估。接受多贝斯治疗的14例患者中只有1例无反应。其余13例临床症状明显改善，疼痛完全缓解，不再需要补充抗酸剂。14例患者中有8例有愈合或明显改善的放射学证据。对照组中无一例患者的疼痛或压痛有任何明显改善，放射学检查也未发现任何变化。该组患者缓解症状所需补充抗酸剂的用量未减少。未出现明显副作用。结论是，多贝斯能加速门诊十二指肠溃疡患者的溃疡愈合，比三硅酸镁能更快、更有效地缓解症状。
