Tanaka Y
Jpn J Physiol. 1979;29(2):181-93. doi: 10.2170/jjphysiol.29.181.
Infusion experiments with Ringer's solution were performed on 5 splenectomized dogs with continuous monitoring of blood volume and hematocrit. The plasma volume was calculated from these data and followed during the infusion and also during the recovery period. Applying electrical equivalent simulation analysis to the result of the plasma volume, the capacitance of the interstitial fluid space and the transvascular filtration coefficient of water in the whole body were determined simultaneously. The mean values of the capacitance and the coefficient were 5.91 ml/kg-mmHg and 0.314 ml/min-kg-mmHg, respectively. From this simulation study, a transfer function which predicts the fluid shift between the vascular system and the interstitial fluid space was also derived. Using the transfer function, predictions of the changes in plasma volume are possible from any given rate of infusion.
对5只脾切除犬进行了林格氏液输注实验，同时持续监测血容量和血细胞比容。根据这些数据计算血浆容量，并在输注过程以及恢复期间进行跟踪。将电等效模拟分析应用于血浆容量的结果，同时测定了间质液空间的电容和全身水的跨血管滤过系数。电容和系数的平均值分别为5.91 ml/kg - mmHg和0.314 ml/min - kg - mmHg。通过该模拟研究，还推导了一个预测血管系统和间质液空间之间液体转移的传递函数。利用该传递函数，可以根据任何给定的输注速率预测血浆容量的变化。
