Gorbacgenkov A A, Savenkov P M, Klevtsova M N, Ozherel'eva N I, Albegov A S
Kardiologiia. 1979 Aug;19(8):95-9.
Visken (pindolol), a blocking agent of adrenergic beta-receptors, was used in the treatment of hypertensive crisis in 30 patients (stage I of the disease in 4, stage II in 23, stage III in 3). Intravenous injfection of visken in a dose of 1 mg led to a decrease of arterial pressure in all patients and relieved the clinical manifestations of crisis completely or partly. Significant reduction of arterial pressure and deceleration of pulse were already in evidence in 5 minutes after injection of the drug. In most patients maximum drop in pressure occurred in 30--60 minutes. There were no complications. As compared to obsidan (propranolol), which was used by other authors in hyperkinetic-type crisis, visken had the same effect on pressure and pulse. The peripheral vasodilator hyperstat (diazoxide) was used in the treatment of crisis in 28 patients with hypertensive disease (stage II of the disease in 21, and stage III in 7). In intravenous injection of 300 mg of hyperstat the hypotensive effect occurred in 1--5 minutes and reached maximum in 5 minutes. A hypotensive and clinical effect was noted in all patients. No complications were observed. On comparison with the results obtained by other authors in hyperstat treatment of hypo- and eukinetic types of crisis no essential difference in the hypotensive effect were noted.
心得静（吲哚洛尔），一种肾上腺素能β受体阻滞剂，用于治疗30例高血压危象患者（疾病I期4例，II期23例，III期3例）。静脉注射1毫克心得静可使所有患者的动脉压下降，并完全或部分缓解危象的临床表现。注射药物后5分钟内，动脉压显著降低且脉搏减慢已很明显。大多数患者在30 - 60分钟内血压降至最大降幅。未出现并发症。与其他作者用于治疗高动力型危象的心得安相比，心得静对血压和脉搏的作用相同。外周血管扩张剂降压嗪（二氮嗪）用于治疗28例高血压病危象患者（疾病II期21例，III期7例）。静脉注射300毫克降压嗪后，1 - 5分钟出现降压效果，5分钟时达到最大效果。所有患者均有降压及临床效果。未观察到并发症。与其他作者用降压嗪治疗低动力型和等动力型危象所获结果相比，降压效果无本质差异。
