Bespalova L A, Shikhodyrov V V, Romanov V S
Kosm Biol Aviakosm Med. 1979 Sep-Oct;13(5):65-9.
Electron microscopy of the liver of dogs exposed to chronic 6-year gamma-irradiation from the CO60 source demonstrated early changes in the hepatocyte structure at a relatively low dosage of 63 rad for 3 years. A comparative study of the submicroscopic reaction of hepatocytes of 3 groups of test dogs showed pronounced changes in the endoplasmatic reticulum: vacuolar transformation balloon dystrophy. The heterogeneity of ultrastructural changes of different hepatocytes was probably associated with a simultaneous development of processes of injury, reparation and adaptation of intracellular structures during the long-term gamma-irradiation exposure. Parallel development of these processes assured reparative biosynthesis to maintain the normal hepatic function.
对暴露于来自钴60源的慢性6年伽马辐射的狗的肝脏进行电子显微镜检查发现，在3年相对低剂量63拉德的情况下，肝细胞结构出现了早期变化。对3组受试狗的肝细胞亚微观反应进行的比较研究显示，内质网有明显变化：空泡样转化、气球样营养不良。不同肝细胞超微结构变化的异质性可能与长期伽马辐射暴露期间细胞内结构损伤、修复和适应过程的同时发生有关。这些过程的平行发展确保了修复性生物合成以维持正常肝功能。
