甲氧苄啶-磺胺甲恶唑与氯霉素治疗伤寒的疗效评估。
Evaluation of therapeutic efficacy of trimethoprim-sulphamethoxazole and chloramphenicol in enteric fever.
作者信息
Kamat S A
出版信息
Br Med J. 1970 Aug 8;3(5718):320-2. doi: 10.1136/bmj.3.5718.320.
Abstract
In a clinical trial on 220 patients with bacteriologically proved enteric fever trimethoprim-sulphamethoxazole was compared with chloramphenicol. All patients in both groups responded, and the mean periods of defervescence after starting therapy were similar in both groups. Trimethoprim-sulphamethoxazole was much superior to chloramphenicol in rapidity and uniformity of relief of toxaemia. "Toxic crisis" occurred in 10 out of 120 patients in the chloramphenicol group and was absent in the trimethoprim-sulphamethoxazole group. No major side-effects due to specific drug therapy were observed in either group.
摘要
在一项针对220例经细菌学证实为肠热症患者的临床试验中，将甲氧苄啶 - 磺胺甲恶唑与氯霉素进行了比较。两组所有患者均有反应，开始治疗后两组的平均退热期相似。在缓解毒血症的速度和一致性方面，甲氧苄啶 - 磺胺甲恶唑远优于氯霉素。氯霉素组120例患者中有10例发生“中毒危机”，而甲氧苄啶 - 磺胺甲恶唑组未出现。两组均未观察到因特定药物治疗引起的严重副作用。
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