Scragg J N, Rubidge C J
Br Med J. 1971 Sep 25;3(5777):738-41. doi: 10.1136/bmj.3.5777.738.
One hundred and three children with proved typhoid fever were treated with trimethoprim-sulphamethoxazole, and the results compared with those of a further 40 children treated with chloramphenicol. The bacteriological response to trimethoprim-sulphamethoxazole was unsatisfactory. From this study it seems that at present chloramphenicol is still the treatment of choice for typhoid fever. In view of the haematological changes occurring during therapy with trimethoprim-sulphamethoxazole caution is necessary and monitoring of the blood picture advisable, even at the recommended dose.
103名确诊为伤寒热的儿童接受了甲氧苄啶-磺胺甲恶唑治疗，并将结果与另外40名接受氯霉素治疗的儿童进行了比较。甲氧苄啶-磺胺甲恶唑的细菌学反应并不理想。从这项研究来看，目前氯霉素似乎仍是治疗伤寒热的首选药物。鉴于在甲氧苄啶-磺胺甲恶唑治疗期间会出现血液学变化，即使是在推荐剂量下，也有必要谨慎用药并建议监测血象。
