Kaye M D, Rhodes J, Beck P, Sweetnam P M, Davies G T, Evans K T
Gut. 1970 Jul;11(7):559-66. doi: 10.1136/gut.11.7.559.
A controlled single-blind trial has been carried out to determine the value of long-term anticholinergic therapy in duodenal ulcer. Of 106 male patients with symptomatic and radiologically proven duodenal ulcer admitted to the trial, 91 completed the study. Patients were divided randomly into three groups. They received either glycopyrronium, or 1-hyoscyamine in a sustained-release form, or inert tablets for one year. Progress was judged on the basis of frequency and severity of symptoms, monthly assessments by patients, antacid consumption, and radiology. By all criteria, glycopyrronium and 1-hyoscyamine were not significantly superior to placebo. Symptomatic improvement, both subjective and objective, occurred in approximately 80% of all patients during the year of observation; there was no significant difference between the groups.
已开展一项对照单盲试验，以确定长期抗胆碱能疗法在十二指肠溃疡治疗中的价值。106名有症状且经放射学证实为十二指肠溃疡的男性患者入选该试验，其中91人完成了研究。患者被随机分为三组。他们分别接受格隆溴铵、缓释型消旋山莨菪碱或惰性片剂治疗，为期一年。根据症状的频率和严重程度、患者每月的评估、抗酸剂的消耗量以及放射学检查来判断病情进展。根据所有标准，格隆溴铵和消旋山莨菪碱并不显著优于安慰剂。在观察期的一年中，约80%的患者主观和客观症状均有改善；各治疗组之间无显著差异。
