Abdulla M, Biörklund A, Mathur A, Wallenius K
J Surg Oncol. 1979;12(2):107-13. doi: 10.1002/jso.2930120203.
Zinc in plasma and whole blood from 13 patients with squamous cell carcinoma of the head and neck was significantly decreased, and the copper:zinc ratio in the plasma was significantly higher than in healthy controls. The plasma zinc was significantly lower in patients who did not respond to therapy and who died within 12 months than in those who responded to therapy and had a remission within 12--15 months. In patients responding to therapy and alive after 12--15 months, zinc in the plasma and whole blood and the copper:zinc ratio became normal. These results suggest a potential screening and predicting value of zinc in the plasma and whole blood and the copper:zinc ratio in squamous cell carcinoma of the head and neck.
13例头颈部鳞状细胞癌患者血浆和全血中的锌显著降低，血浆中的铜锌比显著高于健康对照者。对治疗无反应且在12个月内死亡的患者，其血浆锌显著低于对治疗有反应且在12至15个月内缓解的患者。在对治疗有反应且在12至15个月后仍存活的患者中，血浆和全血中的锌以及铜锌比恢复正常。这些结果表明，血浆和全血中的锌以及铜锌比对头颈部鳞状细胞癌具有潜在的筛查和预测价值。
