Akinmoladun V I, Owotade F J, Olusanya A A
Department of Oral/Maxillofacial Surgery, College of Medicine, University of Ibadan, Oyo State, Nigeria.
Ann Afr Med. 2013 Apr-Jun;12(2):131-4. doi: 10.4103/1596-3519.112411.
BACKGROUND/OBJECTIVE: There are pieces of evidence suggesting that oxidative stress and immune responses play significant roles in the etiopathogenesis of some malignant diseases. Also increased oxidative stress in patients with certain cancer may result from changes in the levels of certain trace elements. Therefore antioxidants either in the form of trace metals or enzymes are important tools in the study of these conditions. This study aimed at measuring the level of oxidative stress in the head and neck cancer patients by using plasma total antioxidant potential and the plasma level of some antioxidant trace metals.
Twenty cases of head and neck squamous cell carcinoma recruited from the Oral and Maxillofacial surgery and Radiotherapy clinics of the University College Hospital, Ibadan were included in the study. While total antioxidant status was measured by ferric reducing antioxidant power (FRAP) assay of Benzie and Strain (1996), the plasma trace metals were assayed by atomic absorption spectrophotometry.
The total antioxidant potential was significantly reduced in the study group when compared with controls. Zinc, iron, and selenium were also found to be significantly lower in the study group compared with controls.
The result suggests a state of oxidative stress in the head and neck cancer patients with likely impact on disease process and treatment outcome.
背景/目的：有证据表明氧化应激和免疫反应在某些恶性疾病的发病机制中起重要作用。此外，某些癌症患者氧化应激增加可能是某些微量元素水平变化所致。因此，无论是微量元素形式还是酶形式的抗氧化剂都是研究这些病症的重要工具。本研究旨在通过检测血浆总抗氧化能力和一些抗氧化微量元素的血浆水平，来测定头颈癌患者的氧化应激水平。
本研究纳入了从伊巴丹大学学院医院口腔颌面外科和放疗科招募的20例头颈鳞状细胞癌患者。通过Benzie和Strain（1996年）的铁还原抗氧化能力（FRAP）测定法检测总抗氧化状态，通过原子吸收分光光度法检测血浆微量元素。
与对照组相比，研究组的总抗氧化能力显著降低。研究组的锌、铁和硒水平也显著低于对照组。
结果表明头颈癌患者存在氧化应激状态，可能会影响疾病进程和治疗结果。
