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卡介苗在豚鼠胸腺中的定位,特别提及哈索尔小体。

The localization of BCG in the guinea-pig thymus with special reference to Hassall's corpuscles.

作者信息

Blau J N

出版信息

Immunology. 1969 Dec;17(6):995-8.

Abstract

Intravenously administered bacillus Calmette—Guérin (BCG) reached the guinea-pig thymus during involution of the gland. Involution occurred either in association with the animal's weight loss, or was produced by local X-irradiation. The latter procedure markedly increased the uptake of bacilli in the thymus. Bacteria were found in greatest concentration in the cortex where globoid cells were seen. However, organisms were also evident inside Hassall's corpuscles. These observations support the concept that Hassall's corpuscles might play a role in long-term immunity.

摘要

静脉注射卡介苗(BCG)在豚鼠胸腺退化期间到达该腺体。退化与动物体重减轻相关联,或者是由局部X射线照射引起的。后一种方法显著增加了胸腺中杆菌的摄取。在可见球状细胞的皮质中发现细菌浓度最高。然而,在哈氏小体内也能明显看到微生物。这些观察结果支持了哈氏小体可能在长期免疫中发挥作用的观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f8d/1456015/41715e4a58d8/immunology00383-0174-a.jpg

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