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卡介苗在豚鼠胸腺中的定位，特别提及哈索尔小体。

The localization of BCG in the guinea-pig thymus with special reference to Hassall's corpuscles.

作者信息

Blau J N

出版信息

Immunology. 1969 Dec;17(6):995-8.

PMID:4917347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1456015/
Abstract

Intravenously administered bacillus Calmette—Guérin (BCG) reached the guinea-pig thymus during involution of the gland. Involution occurred either in association with the animal's weight loss, or was produced by local X-irradiation. The latter procedure markedly increased the uptake of bacilli in the thymus. Bacteria were found in greatest concentration in the cortex where globoid cells were seen. However, organisms were also evident inside Hassall's corpuscles. These observations support the concept that Hassall's corpuscles might play a role in long-term immunity.

摘要

静脉注射卡介苗（BCG）在豚鼠胸腺退化期间到达该腺体。退化与动物体重减轻相关联，或者是由局部X射线照射引起的。后一种方法显著增加了胸腺中杆菌的摄取。在可见球状细胞的皮质中发现细菌浓度最高。然而，在哈氏小体内也能明显看到微生物。这些观察结果支持了哈氏小体可能在长期免疫中发挥作用的观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f8d/1456015/17f840099f88/immunology00383-0175-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f8d/1456015/41715e4a58d8/immunology00383-0174-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f8d/1456015/49be8f7a07d3/immunology00383-0174-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f8d/1456015/17f840099f88/immunology00383-0175-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f8d/1456015/41715e4a58d8/immunology00383-0174-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f8d/1456015/49be8f7a07d3/immunology00383-0174-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f8d/1456015/17f840099f88/immunology00383-0175-a.jpg

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The localization of BCG in the guinea-pig thymus with special reference to Hassall's corpuscles.卡介苗在豚鼠胸腺中的定位，特别提及哈索尔小体。
Immunology. 1969 Dec;17(6):995-8.
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引用本文的文献

1
Similarities between Hassall's corpuscles of the human thymus and the epidermis. An investigation by electron microscopy and histochemistry.人类胸腺哈氏小体与表皮之间的相似性。电子显微镜和组织化学研究。
Cell Tissue Res. 1974;151(3):347-68. doi: 10.1007/BF00224546.

本文引用的文献

1
Hassall's corpuscles: a measure of activity in the thymus during involution and reconstitution.哈索尔小体：胸腺退化和重建过程中胸腺活性的一种衡量指标。
Immunology. 1968 Oct;15(4):561-70.
2
[The modifications of the thymus in the course of experimental tuberculosis in the mouse].[小鼠实验性结核病过程中胸腺的变化]
C R Acad Hebd Seances Acad Sci D. 1968 Mar 18;266(12):1345-8.
3
The dynamic behaviour of Hassall's corpuscles and the transport of particulate matter in the thymus of the guinea-pig.豚鼠胸腺中哈氏小体的动态行为及颗粒物的运输
Immunology. 1967 Sep;13(3):281-92.
4
Antigen and antibody localization in Hassall's corpuscles.抗原和抗体在哈氏小体中的定位。
Nature. 1967 Sep 2;215(5105):1073-5. doi: 10.1038/2151073a0.