一种控制痉挛的新型药物。
A new agent for the control of spasticity.
作者信息
Jones R F, Burke D, Marosszeky J E, Gillies J D
出版信息
J Neurol Neurosurg Psychiatry. 1970 Aug;33(4):464-8. doi: 10.1136/jnnp.33.4.464.
Abstract
In a preliminary controlled trial, CIBA 34,647-Ba, a gamma aminobutyric acid derivative, was found to be more effective than placebo in reducing spasticity due to spinal injuries. In an uncontrolled trial, 34,647-Ba also appeared more effective than diazepam. The intensity of spasticity was measured electromyographically by the amplitude of the stretch reflex at various velocities, and the results were correlated with those obtained by clinical assessment. 34,647-Ba was effective in both complete and incomplete spinal cord lesions and it is suggested that it has an action at the spinal level. No significant side-effects were encountered.
摘要
在一项初步对照试验中，发现γ-氨基丁酸衍生物CIBA 34,647-Ba在减轻脊髓损伤所致痉挛方面比安慰剂更有效。在一项非对照试验中，34,647-Ba似乎也比地西泮更有效。通过不同速度下牵张反射的幅度，用电肌描记法测量痉挛强度，并将结果与临床评估结果相关联。34,647-Ba对完全性和不完全性脊髓损伤均有效，提示其作用于脊髓水平。未发现明显副作用。
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