淋巴细胞数量少于一百万的动物免疫反应的个体发生：产婆蟾的幼体。
Ontogeny of the immune response in animals having less than one million lymphocytes: the larvae of the toad Alytes obstetricans.
作者信息
Du Pasquier L
出版信息
Immunology. 1970 Aug;19(2):353-62.
Abstract
The larvae of the toad , the spleen of which has at least 6000 lymphoid cells, are able to mount an immune response against sheep or human red blood cells. The study of the ontogeny of the spleen shows that even if it contains as little as 500–1000 cells, there is always at least one cell able to react with the antigen. The ability to induce a primary response (plaque forming cells and immune rosette forming cells) appears when the number of cells in the spleen reaches 6000–12,000.
摘要
蟾蜍的幼虫，其脾脏至少有6000个淋巴细胞，能够对绵羊或人类红细胞产生免疫反应。对脾脏个体发育的研究表明，即使脾脏中细胞数量少至500 - 1000个，也总会有至少一个细胞能够与抗原发生反应。当脾脏中的细胞数量达到6000 - 12000个时，诱导初级反应（噬斑形成细胞和免疫玫瑰花结形成细胞）的能力就会出现。
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本文引用的文献
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Plaque Formation in Agar by Single Antibody-Producing Cells.琼脂中由单个抗体产生细胞形成的斑块。
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APPLICATION OF A LOCALIZED HEMOLYSIN REACTION FOR SPECIFIC DETECTION OF INDIVIDUAL ANTIBODY-FORMING CELLS.局部溶血素反应在个体抗体形成细胞特异性检测中的应用。
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