慢性肾衰竭和血液透析患者的血清铁蛋白测定与铁状态
Serum ferritin assay and iron status in chronic renal failure and haemodialysis.
作者信息
Hussein S, Prieto J, O'Shea M, Hoffbrand A V, Baillod R A, Moorhead J F
出版信息
Br Med J. 1975 Mar 8;1(5957):546-8. doi: 10.1136/bmj.1.5957.546.
Abstract
Forty-four patients with chronic renal failure on haemodialysis for four months to eight years were studied. All recieved intravenous iron dextran 100 mg on alternate weeks. Serum ferritin concentrations correlated well with body iron stores estimated by grading the bone marrow stainable iron. Altogether 34 patients showed increased bone marrow iron stores and serum ferritin concentrations greater than controls; four patients showed absence of iron in the marrow, and three of these had subnormal serum ferritin concentrations. Serum ferritin assay represents the best method of repeatedly monitoring the exact amount of iron therapy needed by patients with chronic renal failure, particularly those on regular haemodialysis.
摘要
对44例接受血液透析4个月至8年的慢性肾衰竭患者进行了研究。所有患者每隔一周接受100毫克静脉注射右旋糖酐铁。血清铁蛋白浓度与通过对骨髓可染色铁进行分级估计的体内铁储存量密切相关。共有34例患者骨髓铁储存增加，血清铁蛋白浓度高于对照组；4例患者骨髓中无铁，其中3例血清铁蛋白浓度低于正常水平。血清铁蛋白检测是反复监测慢性肾衰竭患者，尤其是定期接受血液透析患者所需铁治疗准确剂量的最佳方法。
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