Stave U
Monatsschr Kinderheilkd (1902). 1979 Oct;127(10):621-7.
While the high risk infants' prognosis for normal development has been greatly improved by modern neonatal intensive care, premature birth, low birthweight and perinatal complications involving compromised brain function still represent major risk factors. Different criteria for admission and assessment methods are the reason that recent publications cite neurological sequelae in high risk infants that range from 4.4 to 28%. The need for an effective screening instrument enableing the pediatrician to test and evaluate neurological function, maturation and integrity, is quite obvious. The author has selected a group of neurological items according to results of Touwen's (1976) longitudinal study on neurological maturation in infancy. In addition, Prechtl's (1968) optimality concept was applied in our study. This new standardized neurological examination was used to evaluate 163 high risk infants with a corrected age of 3 and 6 months. The results demonstrate statistically significant differences between the neurological status of full-term and premature infants, and similarly between those with minimal risk and perinatal brain distress. The rather steep increase of neurological optimality scores by age of 6 months implies a high rate of self-repair or catch-up in maturation of the nervous system. We speculate that early extrauterine stimulation of the premature does not accelerate the development of brain function in a similar way as it does other organ functions, but it may slow down maturation.
尽管现代新生儿重症监护极大地改善了高危婴儿正常发育的预后,但早产、低出生体重以及涉及脑功能受损的围产期并发症仍然是主要风险因素。不同的入院标准和评估方法导致近期出版物中报道的高危婴儿神经后遗症发生率在4.4%至28%之间。显然需要一种有效的筛查工具,使儿科医生能够测试和评估神经功能、成熟度和完整性。作者根据图温(1976年)关于婴儿期神经成熟的纵向研究结果,选择了一组神经项目。此外,普雷赫特尔(1968年)的最优性概念也应用于我们的研究。这项新的标准化神经检查用于评估163名矫正年龄为3个月和6个月的高危婴儿。结果表明,足月儿和早产儿的神经状态之间存在统计学上的显著差异,同样,低风险婴儿和围产期脑损伤婴儿之间也存在显著差异。到6个月大时,神经最优性评分的显著增加意味着神经系统成熟过程中自我修复或追赶的比例很高。我们推测,对早产儿进行早期宫外刺激并不会像对其他器官功能那样加速脑功能的发育,但可能会减缓成熟过程。