Warren B A, de Bono A H
Br J Exp Pathol. 1970 Aug;51(4):415-22.
The ultrastructure of the early aggregation of platelets was studied in homografts of lung and heart in 5 dogs. Because of the vascularity of the lung this tissue provided an opportunity to observe various stages in the aggregation of platelets following endothelial damage in vivo. The different steps involved in platelet aggregation from the formation of spiky processes to the production of the complete platelet aggregate associated with fibrin were examined. Damaged endothelial cells in this situation did not induce the adhesion of platelets, even when their immediately underlying basement membrane was covered by a platelet layer 3 cells thick. In some areas fibrin strands occurred between the platelets of this layer, but these fibrin strands did not extend beyond the platelet laminae.
对5只狗的肺和心脏同种移植中血小板早期聚集的超微结构进行了研究。由于肺的血管分布，该组织为观察体内内皮损伤后血小板聚集的各个阶段提供了机会。研究了从棘状突起形成到与纤维蛋白相关的完整血小板聚集体产生过程中血小板聚集所涉及的不同步骤。在这种情况下，受损的内皮细胞不会诱导血小板黏附，即使其紧邻的基底膜被3层细胞厚的血小板层覆盖。在该层血小板之间的某些区域出现了纤维蛋白丝，但这些纤维蛋白丝并未延伸到血小板薄片之外。
