Warren B A, de Bono A H
Br J Exp Pathol. 1969 Dec;50(6):593-9.
The ultrastructure of early rejection phenomena was studied in homografts of lung in 5 dogs. There was considerable variation in the time interval from transplantation to indication of early damage. The evolution of changes, once begun, followed a regular pattern. The features which characterised these changes were margination of leucocytes, sticking of lymphocytes to endothelial cells, progressive disintegration of neutrophil leucocytes, swelling and exfoliation of endothelial cells from the basement membrane of pulmonary capillaries and platelet aggregation. The end result was obstruction of some pulmonary capillaries by debris from damaged neutrophils, exfoliated endothelial cells, ballooned out endothelial cells, platelet aggregates, and fibrin.
对5只狗的肺同种移植早期排斥现象的超微结构进行了研究。从移植到出现早期损伤迹象的时间间隔有很大差异。一旦开始，变化的发展遵循一定规律。这些变化的特征包括白细胞边缘化、淋巴细胞黏附于内皮细胞、中性粒细胞逐渐解体、肺毛细血管基底膜处的内皮细胞肿胀和脱落以及血小板聚集。最终结果是受损中性粒细胞的碎片、脱落的内皮细胞、肿胀的内皮细胞、血小板聚集体和纤维蛋白阻塞了一些肺毛细血管。
