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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Wiegand H, Wellhöner H H

Naunyn Schmiedebergs Arch Pharmacol. 1979 Jul;308(1):71-6. doi: 10.1007/BF00499722.

After injection of tetanus toxin into the gastrocnemius muscle of the cat non-synaptic excitability of motoneurones was studied in early local tetanus. Antidromic stimulation of motoneurones was performed onthe toxin-treated side and on the control side of the same cat. 2. The mean resting membrane potential of the motoneurones on the toxin-treated side did not differ from that on the control side. 3. Similarly, no differences were found as to the amplitude of the action potential and its rate of rise as well as to the size and time course of the after-hyperpolarization. 4. The mean input resistance of the motoneurones of the toxintreated side did not differ from that of the motoneurones of the control side. 5. Tetanus toxin did not change the mean refractory period and latency of antidromic responses. 6. It is concluded that the action of tetanus toxin the spinal cord cannot be explained by an action of the toxin on the electrically excitable membrane elements of the motoneurones.

将破伤风毒素注入猫的腓肠肌后，在早期局部破伤风状态下研究了运动神经元的非突触兴奋性。在同一只猫的毒素处理侧和对照侧对运动神经元进行逆向刺激。2. 毒素处理侧运动神经元的平均静息膜电位与对照侧无差异。3. 同样，在动作电位的幅度及其上升速率以及后超极化的大小和时程方面未发现差异。4. 毒素处理侧运动神经元的平均输入电阻与对照侧运动神经元的平均输入电阻无差异。5. 破伤风毒素未改变逆向反应的平均不应期和潜伏期。6. 得出的结论是，破伤风毒素对脊髓的作用不能用毒素对运动神经元电兴奋性膜成分的作用来解释。

Wiegand H, Wellhöner H H

Naunyn Schmiedebergs Arch Pharmacol. 1979 Jul;308(1):71-6. doi: 10.1007/BF00499722.

After injection of tetanus toxin into the gastrocnemius muscle of the cat non-synaptic excitability of motoneurones was studied in early local tetanus. Antidromic stimulation of motoneurones was performed onthe toxin-treated side and on the control side of the same cat. 2. The mean resting membrane potential of the motoneurones on the toxin-treated side did not differ from that on the control side. 3. Similarly, no differences were found as to the amplitude of the action potential and its rate of rise as well as to the size and time course of the after-hyperpolarization. 4. The mean input resistance of the motoneurones of the toxintreated side did not differ from that of the motoneurones of the control side. 5. Tetanus toxin did not change the mean refractory period and latency of antidromic responses. 6. It is concluded that the action of tetanus toxin the spinal cord cannot be explained by an action of the toxin on the electrically excitable membrane elements of the motoneurones.

将破伤风毒素注入猫的腓肠肌后，在早期局部破伤风状态下研究了运动神经元的非突触兴奋性。在同一只猫的毒素处理侧和对照侧对运动神经元进行逆向刺激。2. 毒素处理侧运动神经元的平均静息膜电位与对照侧无差异。3. 同样，在动作电位的幅度及其上升速率以及后超极化的大小和时程方面未发现差异。4. 毒素处理侧运动神经元的平均输入电阻与对照侧运动神经元的平均输入电阻无差异。5. 破伤风毒素未改变逆向反应的平均不应期和潜伏期。6. 得出的结论是，破伤风毒素对脊髓的作用不能用毒素对运动神经元电兴奋性膜成分的作用来解释。