Pritzker K P, Huang S N, Marshall K G
Can Med Assoc J. 1970 Dec 19;103(13):1362-5.
Two cases of malignant disease occurring during immunosuppressive therapy, one a leiomyosarcoma of bowel metastatic to the liver, the other, carcinoma in situ of the cervix uteri, are reported. The possible roles of immunosuppression and immunosuppressive therapy in the pathogenesis of these neoplasms are discussed. It is suggested that the incidence of neoplasms in immunologically suppressed patients is greatly increased and that further investigation into the relation of immunosuppression to cancer is urgently needed.
报告了两例在免疫抑制治疗期间发生的恶性疾病，一例是肠道平滑肌肉瘤转移至肝脏，另一例是子宫颈原位癌。讨论了免疫抑制和免疫抑制治疗在这些肿瘤发病机制中的可能作用。提示免疫抑制患者的肿瘤发病率大大增加，迫切需要进一步研究免疫抑制与癌症的关系。
