Baldwin G S, Carnegie P R
Science. 1971 Feb 12;171(3971):579-81. doi: 10.1126/science.171.3971.579.
A cytoplasmic enzyme from guinea pig brain was shown to transfer methyl groups from S-adenosylmethionine to only one of 19 arginine residues in the basic protein from human brain. The products were omega-N-monomethylarginine and omega-N,N'-dimethylarginine. These methylated arginines are adjacent to the main encephalitogenic determinant in the protein. Methylation may aid in the transfer of this region of the protein into the nonpolar environment within myelin and in maintaining the integrity of myelin.
已证明，豚鼠脑内的一种胞质酶可将S-腺苷甲硫氨酸的甲基基团转移至人脑碱性蛋白19个精氨酸残基中的仅一个。产物为ω-N-单甲基精氨酸和ω-N，N'-二甲基精氨酸。这些甲基化的精氨酸毗邻该蛋白中的主要致脑炎性决定簇。甲基化可能有助于该蛋白的这一区域转移至髓鞘内的非极性环境中，并有助于维持髓鞘的完整性。
