从髓磷脂致脑炎碱性蛋白中分离甲基化精氨酸并进行部分特性鉴定。
Isolation and partial characterization of methylated arginines from the encephalitogenic basic protein of myelin.
作者信息
Baldwin G S, Carnegie P R
出版信息
Biochem J. 1971 Jun;123(1):69-74. doi: 10.1042/bj1230069.
Abstract
Two methylated derivatives of arginine were isolated from the encephalitogenic protein of myelin from the central nervous system. Evidence is presented for the proposed structures, omega-NN'-dimethylarginine and omega-N-monomethylarginine. In the encephalitogenic protein from human brain the proportion 1:6:10 for arginine:monomethylarginine:dimethylarginine residues was found to occur at position 107. Possible roles for the methylated arginine in conformational changes and altered ion-exchange behaviour are discussed.
摘要
从中枢神经系统髓鞘的致脑炎蛋白中分离出两种精氨酸的甲基化衍生物。文中给出了关于所提出的结构——ω-NN'-二甲基精氨酸和ω-N-单甲基精氨酸的证据。在来自人脑的致脑炎蛋白中，发现精氨酸:单甲基精氨酸:二甲基精氨酸残基的比例为1:6:10，位于第107位。讨论了甲基化精氨酸在构象变化和离子交换行为改变中的可能作用。
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