Paul C, Shimizu A, Köhler H, Putnam F W
Science. 1971 Apr 2;172(3978):69-72. doi: 10.1126/science.172.3978.69.
The amino acid sequence around the central disulfide bridge linking the mu heavy chains of the human immunoglobulin M monomer is unlike that in immunoglobulin G. This hinge area contains one of the five oligosaccharides of the mu chain, is low in proline, and is the site of tryptic cleavage to yield Fabmicro and Fcmicro fragments.
连接人免疫球蛋白M单体μ重链的中心二硫键周围的氨基酸序列与免疫球蛋白G中的不同。这个铰链区含有μ链的五种寡糖之一，脯氨酸含量低，是胰蛋白酶裂解产生Fabμ和Fcμ片段的位点。
