Hollister L E
Science. 1971 Apr 2;172(3978):21-9. doi: 10.1126/science.172.3978.21.
The past 3 years of renewed research on the effects of marihuana in man has added little not previously known about the clinical syndromes produced by the drug. The major advance has been a quantification of dose in relation to clinical phenomena, and a beginning of an understanding of the drug's metabolism. The crucial clinical experiments in regard to the social questions about marihuana, such as the possible deleterious effects from chronic use, cannot be answered by laboratory experiments. These must be settled by close observations made on those who experiment on themselves. It should be possible, within a relatively short time, to determine whether marihuana has any medical utility, but the future would appear to be no more promising than the past in this regard. The mechanisms by which marihuana alters mental functions are not likely to be answered in man, nor even answered soon by animal studies. As marihuana may be unique among drugs in that more experimentation has been accomplished in man than in animals, it may be necessary to look to additional animal studies to provide leads for pertinent future studies in man.
在过去三年里，对大麻对人体影响的重新研究几乎没有增加任何关于该药物所产生临床综合征的此前未知信息。主要进展在于对剂量与临床现象之间关系的量化，以及对药物代谢理解的开端。关于大麻的社会问题，如长期使用可能产生的有害影响等关键临床实验，无法通过实验室实验来回答。这些问题必须通过对自我实验者的密切观察来解决。在相对较短的时间内，应该有可能确定大麻是否具有任何医学用途，但在这方面，未来似乎并不比过去更有希望。大麻改变心理功能的机制在人类身上不太可能得到解答，甚至在动物研究中也不太可能很快得到解答。由于大麻在药物中可能是独特的，因为在人体上进行的实验比在动物身上更多，可能有必要寻求更多的动物研究，为未来有关人类的相关研究提供线索。
