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1
Antigen-binding cells in mice immune or tolerant to Escherichia coli polysaccharide.对大肠杆菌多糖免疫或耐受的小鼠中的抗原结合细胞。
J Exp Med. 1971 May 1;133(5):1015-25. doi: 10.1084/jem.133.5.1015.
2
Immunoglobulin and other surface antigens of cells of the immune system.免疫系统细胞的免疫球蛋白及其他表面抗原。
J Exp Med. 1971 Oct 1;134(4):815-32. doi: 10.1084/jem.134.4.815.
3
Induction of antigenic competition with thymus-dependent antigens: effect on DNA synthesis in spleen cells.胸腺依赖性抗原诱导抗原竞争：对脾细胞DNA合成的影响。
J Immunol. 1971 Jun;106(6):1566-71.
4
Cell interactions in the immune response in vitro. V. Specific collaboration via complexes of antigen and thymus-derived cell immunoglobulin.体外免疫反应中的细胞相互作用。V. 通过抗原与胸腺来源细胞免疫球蛋白复合物的特异性协作。
J Exp Med. 1972 Oct 1;136(4):737-60. doi: 10.1084/jem.136.4.737.
5
Nonspecific elicitation of antibody-forming cells in the mouse spleen by bacterial lipopolysaccharide.细菌脂多糖对小鼠脾脏中抗体形成细胞的非特异性诱导
Jpn J Microbiol. 1975 Apr;19(2):141-8. doi: 10.1111/j.1348-0421.1975.tb00860.x.
6
Antibody formation in mouse bone marrow. V. The response to the thymus-independent antigen Ecsherichia coli lipopolysaccharide.小鼠骨髓中的抗体形成。V. 对胸腺非依赖性抗原大肠杆菌脂多糖的反应。
Immunology. 1976 Jan;30(1):49-57.
7
Antigen-binding cells in immune and tolerant animals.免疫和耐受动物中的抗原结合细胞。
Transplant Rev. 1972;8:26-49.
8
Cells involved in the immune response. XXXIV: Suppressor cells in the thymus of the immunized rabbit capable of secreting a factor which can suppress the secretion of antibodies from antibody-forming cells in vitro.参与免疫反应的细胞。三十四：免疫兔胸腺中的抑制细胞，其能够分泌一种因子，该因子在体外可抑制抗体形成细胞分泌抗体。
Clin Immunol Immunopathol. 1986 Dec;41(3):461-78. doi: 10.1016/0090-1229(86)90017-6.
9
Immune response suppression by an inhibitor in normal and immune mouse serum.正常小鼠血清和免疫小鼠血清中抑制剂对免疫反应的抑制作用。
Nat New Biol. 1972 Feb 23;235(60):238-40. doi: 10.1038/newbio235238a0.
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THE MECHANISM OF TOLERANCE PRODUCED IN RATS TO SHEEP ERYTHROCYTES. II. THE PLAQUE-FORMING CELL AND ANTIBODY RESPONSE TO MULTIPLE INJECTIONS OF ANTIGEN BEGUN AT BIRTH.大鼠对绵羊红细胞产生耐受性的机制。II. 对出生时开始多次注射抗原的空斑形成细胞及抗体反应
J Exp Med. 1965 May 1;121(5):683-95. doi: 10.1084/jem.121.5.683.

引用本文的文献

1
Development of chicken lymphoid system. II. Synthesis of primordial immunoglobulin M by the bursa cells of chick embryo.鸡淋巴系统的发育。II. 鸡胚法氏囊细胞合成原始免疫球蛋白M
J Exp Med. 1972 Jul 1;136(1):8-20. doi: 10.1084/jem.136.1.8.
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The primary and secondary antibody response to Escherichia coli O6 lipopolysaccharide analysed at the humoral and cellular level. Amount and avidity of the antibodies in relation to protective capacity.在体液和细胞水平分析对大肠杆菌O6脂多糖的初次和二次抗体反应。抗体的数量和亲和力与保护能力的关系。
Immunology. 1973 Feb;24(2):191-202.
3
Regulation of autosensitization. The immune activation and specific inhibition of self-recognizing thymus-derived lymphocytes.自身致敏的调节。免疫激活以及对识别自身的胸腺来源淋巴细胞的特异性抑制。
J Exp Med. 1973 Feb 1;137(2):224-38. doi: 10.1084/jem.137.2.224.
4
The production of IgE and IgG1 antibodies in guinea-pigs immunized with antigen and bacterial lipopolysaccharides.用抗原和细菌脂多糖免疫的豚鼠中IgE和IgG1抗体的产生。
Immunology. 1973 Aug;25(2):297-305.
5
Genetical control of B-cell responses. III. Requirement for functional mitogenicity of the antigen in thymus-independent specific responses.B细胞应答的遗传控制。III. 非胸腺依赖性特异性应答中抗原功能性促有丝分裂活性的需求。
J Exp Med. 1975 Apr 1;141(4):753-60.
6
Permanent hapten-specific tolerance in B lymphocytes.B淋巴细胞中的永久性半抗原特异性耐受。
Immunology. 1975 Mar;28(3):543-52.
7
Immunological tolerance: high-dose antigen-induced suppressor cells from tolerant animals inactivate antigen-presenting macrophages.免疫耐受：来自耐受动物的高剂量抗原诱导的抑制细胞使抗原呈递巨噬细胞失活。
Proc Natl Acad Sci U S A. 1979 May;76(5):2405-9. doi: 10.1073/pnas.76.5.2405.

本文引用的文献

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Plaque Formation in Agar by Single Antibody-Producing Cells.琼脂中由单个抗体产生细胞形成的斑块。
Science. 1963 Apr 26;140(3565):405. doi: 10.1126/science.140.3565.405.
2
A SIMPLE METHOD FOR DETECTING SINGLE ANTIBODY-FORMING CELLS.一种检测单个抗体形成细胞的简单方法。
Nature. 1964 Jun 20;202:1231. doi: 10.1038/2021231a0.
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STUDIES ON GLOBULIN AND ANTIBODY PRODUCTION IN MICE THYMECTOMIZED AT BIRTH.新生期切除胸腺的小鼠球蛋白和抗体生成的研究。
Immunology. 1964 Jul;7(4):419-39.
4
[IMMUNO-CYTO-ADHESION: A SIMPLE AND QUANTITATIVE METHOD FOR THE STUDY IN VITRO OF ANTIBODY-PRODUCING CELLS].[免疫细胞黏附：一种用于体外研究抗体产生细胞的简单定量方法]
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5
Studies of enterobacterial lipopolysaccharides; effects of heat and chemicals on erythrocyte-modifying, antigenic, toxic and pyrogenic properties.肠杆菌脂多糖的研究；热和化学物质对红细胞修饰、抗原性、毒性及致热特性的影响。
J Immunol. 1956 May;76(5):377-85.
6
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
7
Binding of 125I-BSA to lymphoid cells of tolerant mice.125I标记的牛血清白蛋白与耐受小鼠淋巴细胞的结合
Int Arch Allergy Appl Immunol. 1969;36(1):112-3. doi: 10.1159/000230728.
8
Selection of cell populations in induction of tolerance: affinity of antibody formed in partially tolerant rabbits.诱导耐受过程中细胞群体的选择：部分耐受兔体内形成抗体的亲和力
J Immunol. 1968 Jan;100(1):138-41.
9
Antigen binding cells in tolerance and immunity.耐受性和免疫中的抗原结合细胞。
Transplant Rev. 1970;5:105-29. doi: 10.1111/j.1600-065x.1970.tb00358.x.
10
Studies on antigen-binding cells. I. The origin of reactive cells.抗原结合细胞的研究。I. 反应性细胞的起源。
Cell Immunol. 1970 Oct;1(4):372-85. doi: 10.1016/0008-8749(70)90015-8.

对大肠杆菌多糖免疫或耐受的小鼠中的抗原结合细胞。

Antigen-binding cells in mice immune or tolerant to Escherichia coli polysaccharide.

作者信息

Sjöberg O

出版信息

J Exp Med. 1971 May 1;133(5):1015-25. doi: 10.1084/jem.133.5.1015.

DOI:10.1084/jem.133.5.1015
PMID:4928815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2138916/
Abstract

The number of PFC and of RFC was studied in mice which were unimmunized, immunized, or tolerant against lipopolysaccharide of E. coli 055:B5 origin. The number of PFC/10(6) spleen cells increased from 0.5 in normal to 209 in immunized mice. The corresponding figures for RFC were 93 and 513 RFC/10(6) spleen cells. In tolerant animals, which contained few or no PFC, the number of RFC was increased as compared to that found in unimmunized mice. The formation of rosettes was specific, since their formation was inhibited by soluble coli polysaccharide and by rabbit antisera against mouse immunoglobulins. The antigen-binding cells were not derived from thymus, neither in immune or tolerant mice, because they did not carry the theta antigen. It is suggested that the majority of antigen-binding cells present in tolerant animals are cells having receptors for the antigen of rather low affinity. The relevance of these findings for the induction of high and low zone tolerance is discussed.

摘要

对未免疫、免疫或对源自大肠杆菌055:B5的脂多糖耐受的小鼠，研究了其PFC（空斑形成细胞）和RFC（玫瑰花结形成细胞）的数量。PFC/10⁶脾细胞数量从正常小鼠的0.5增加到免疫小鼠的209。RFC的相应数字分别为93和513 RFC/10⁶脾细胞。在几乎不含或不含PFC的耐受动物中，RFC数量比未免疫小鼠有所增加。玫瑰花结的形成具有特异性，因为其形成受到可溶性大肠杆菌多糖和兔抗小鼠免疫球蛋白血清的抑制。在免疫或耐受小鼠中，抗原结合细胞均非来源于胸腺，因为它们不携带θ抗原。有人提出，耐受动物中存在的大多数抗原结合细胞是对抗原亲和力相当低的具有受体的细胞。讨论了这些发现与高区和低区耐受诱导的相关性。