Bonney R J, Weinfeld H
J Bacteriol. 1971 Mar;105(3):940-6. doi: 10.1128/jb.105.3.940-946.1971.
In Escherichia coli K-12, the rise in activity of thymidine phosphorylase, phosphodeoxyribomutase, and deoxyribose-5-phosphate aldolase caused by exogenous thymidine is dependent on the synthesis of new enzyme protein. Phosphodeoxyribomutase is induced by the purine ribonucleosides adenosine and guanosine, whereas the other two enzymes are not. The mutase activity induced by thymidine and by the purine ribonucleosides has been shown to be the same enzyme by four different criteria. This independent induction of phosphodeoxyribomutase suggests that the gene for this enzyme is in an operon different from the one that may contain the genes for thymidine phosphorylase and deoxyribose-5-phosphate aldolase.
在大肠杆菌K-12中，外源胸苷引起的胸苷磷酸化酶、磷酸脱氧核糖变位酶和脱氧核糖-5-磷酸醛缩酶活性的升高依赖于新酶蛋白的合成。磷酸脱氧核糖变位酶由嘌呤核糖核苷腺苷和鸟苷诱导，而其他两种酶则不然。通过四种不同的标准已表明，由胸苷和嘌呤核糖核苷诱导的变位酶活性是同一种酶。磷酸脱氧核糖变位酶的这种独立诱导表明，该酶的基因位于一个与可能包含胸苷磷酸化酶和脱氧核糖-5-磷酸醛缩酶基因的操纵子不同的操纵子中。
