硫唑嘌呤与泼尼松治疗慢性肾病的对照试验。医学研究委员会工作组报告
Controlled trial of azathioprine and prednisone in chronic renal disease. Report by Medical Research Council Working Party.
出版信息
Br Med J. 1971 May 1;2(5756):239-41.
Abstract
Patients with various forms of glomerulonephritis, but excluding those with minimal glomerular changes, were admitted to a controlled trial of a regimen which combined azathioprine in a dosage of 2.5 mg/kg/day with prednisone in a dosage of 20 mg/day (adults) or 0.5 mg/kg/day (children). Of 149 patients included, 32 of them under the age of 15, 72 were randomly allocated to the "treatment" group and 77 to the "control" group. There was no evidence of benefit from the treatment group as a whole; and the mortality was in fact higher in the treated group.
摘要
患有各种形式肾小球肾炎的患者，但不包括那些肾小球变化轻微的患者，被纳入一项对照试验，该试验采用一种联合治疗方案，即硫唑嘌呤剂量为2.5毫克/千克/天，泼尼松剂量为20毫克/天（成人）或0.5毫克/千克/天（儿童）。在纳入的149例患者中，其中32例年龄在15岁以下，72例被随机分配到“治疗”组，77例被分配到“对照”组。总体而言，没有证据表明治疗组有获益；事实上，治疗组的死亡率更高。
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2
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Br Med J. 1970 Aug 22;3(5720):421-6. doi: 10.1136/bmj.3.5720.421.
3
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Br Med J. 1970 Jul 18;3(5715):167. doi: 10.1136/bmj.3.5715.167-a.
4
Controlled trial of cyclophosphamide in steroid-sensitive relapsing nephrotic syndrome of childhood.
Lancet. 1970 Sep 5;2(7671):479-82. doi: 10.1016/s0140-6736(70)90108-x.
5
Clinicopathological study of nephrotic syndrome in childhood.儿童肾病综合征的临床病理研究
Lancet. 1970 Jun 27;1(7661):1353-9. doi: 10.1016/s0140-6736(70)91268-7.
6
Controlled trial of azathioprine in children with nephrotic syndrome. A report for the international study of kidney disease in children.
Lancet. 1970 May 9;1(7654):959-61. doi: 10.1016/s0140-6736(70)91093-7.
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