Br Med J. 1971 May 1;2(5756):239-41.
Patients with various forms of glomerulonephritis, but excluding those with minimal glomerular changes, were admitted to a controlled trial of a regimen which combined azathioprine in a dosage of 2.5 mg/kg/day with prednisone in a dosage of 20 mg/day (adults) or 0.5 mg/kg/day (children). Of 149 patients included, 32 of them under the age of 15, 72 were randomly allocated to the "treatment" group and 77 to the "control" group. There was no evidence of benefit from the treatment group as a whole; and the mortality was in fact higher in the treated group.
患有各种形式肾小球肾炎的患者，但不包括那些肾小球变化轻微的患者，被纳入一项对照试验，该试验采用一种联合治疗方案，即硫唑嘌呤剂量为2.5毫克/千克/天，泼尼松剂量为20毫克/天（成人）或0.5毫克/千克/天（儿童）。在纳入的149例患者中，其中32例年龄在15岁以下，72例被随机分配到“治疗”组，77例被分配到“对照”组。总体而言，没有证据表明治疗组有获益；事实上，治疗组的死亡率更高。
