中枢神经系统畸形与当地供水软化
Malformations of central nervous system and softness of local water supplies.
作者信息
Lowe C R, Roberts C J, Lloyd S
出版信息
Br Med J. 1971 May 15;2(5758):357-61. doi: 10.1136/bmj.2.5758.357.
Abstract
The mean annual prevalence at birth of congenital malformations of the central nervous system for the three years 1964-6 in 48 local authority areas in South Wales was negatively correlated (r = -0.402, P<0.01) with estimates of the mean total hardness of the related water supplies.The mean annual perinatal mortality rate from anencephalus for the five years 1963-7 in 58 county boroughs in England and Wales was also negatively correlated with estimates of the mean total hardness (r = -0.220, P>0.05) and calcium content (r = -0.289, P<0.05) of the related water supplies.It is concluded that the relationship between these associations may well be secondary. Analytical epidemiological studies of the association are called for.
摘要
1964 - 1966年期间，南威尔士48个地方政府辖区内出生时中枢神经系统先天性畸形的年平均患病率与相关供水的平均总硬度估计值呈负相关（r = -0.402，P<0.01）。1963 - 1967年期间，英格兰和威尔士58个郡级市无脑儿的年平均围产期死亡率也与相关供水的平均总硬度估计值（r = -0.220，P>0.05）和钙含量估计值（r = -0.289，P<0.05）呈负相关。得出的结论是，这些关联之间的关系很可能是次要的。需要对这种关联进行分析性流行病学研究。
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