神经管畸形与水中的微量元素
Neural tube malformations and trace elements in water.
作者信息
Leger A S, Elwood P C, Morton M S
出版信息
J Epidemiol Community Health. 1980 Sep;34(3):186-7. doi: 10.1136/jech.34.3.186.
A retrospective case-control study was conducted to test the hypothesis that there is an association between the trace element content of domestic tap water and neural tube malformations in infants. Of 11 elements examined a notable difference was found only for zinc, this being lower in the cases than in the controls. This difference, however, was small and when allowance is made for the total number of statistical comparisons it is compatible with chance fluctuation. From the results of this study, together with the inconsistency of the literature as a whole, it is concluded that trace elements in tap water are unlikely to be of relevance to congenital malformations.
开展了一项回顾性病例对照研究，以检验关于家庭自来水中微量元素含量与婴儿神经管畸形之间存在关联的假设。在所检测的11种元素中，仅发现锌存在显著差异，病例组中的锌含量低于对照组。然而，这种差异很小，考虑到统计比较的总数，它可能是随机波动造成的。根据本研究结果，结合整个文献的不一致性，得出的结论是，自来水中的微量元素不太可能与先天性畸形有关。
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