Addison I E, Berenbaum M C
Br J Cancer. 1971 Mar;25(1):172-81. doi: 10.1038/bjc.1971.24.
The effect of cysteine on the immunosuppressive activity of three alkylating agents was tested. Cysteine strongly inhibited the ability of cyclophosphamide and nitrogen mustard to depress the direct plaque-forming cell response of mice to sheep red cells. In contrast, the activity of busulphan was usually potentiated by administration of cysteine. This throws doubt on the hypothesis that busulphan exerts its cytotoxic effects by alkylating thiol groups.
测试了半胱氨酸对三种烷化剂免疫抑制活性的影响。半胱氨酸强烈抑制环磷酰胺和氮芥降低小鼠对绵羊红细胞直接空斑形成细胞反应的能力。相比之下，给予半胱氨酸通常会增强白消安的活性。这对关于白消安通过烷化巯基发挥其细胞毒性作用的假说提出了质疑。
