Ohno R, Harris J E, Hersh E M
Clin Exp Immunol. 1970 Aug;7(2):221-7.
L-asparaginase was immunosuppressive in mice. A single injection of 1000 I.U. of L-asparaginase markedly suppressed the direct haemolytic plaque forming cell response to immunization with sheep red blood cells. The effect was not due to cytotoxicity but to delayed proliferation of plaque forming cells. Haemagglutinin production was delayed by a single injection and was suppressed when the enzyme was given daily from 3 days before immunization to the day before antiserum collection. L-asparaginase in this dosage form both reduced total antibody production and markedly prolonged 2-ME sensitive antibody production. L-asparaginase treatment was only weakly immunosuppressive and none of the animals studied showed complete suppression of the immune response. It was suggested that asparaginase would be most effective in the prevention of the development of primary immunity when combined with another agent with an independent mechanism of action.
L-天冬酰胺酶在小鼠体内具有免疫抑制作用。单次注射1000国际单位的L-天冬酰胺酶可显著抑制针对绵羊红细胞免疫的直接溶血空斑形成细胞反应。这种作用并非由于细胞毒性，而是由于空斑形成细胞的增殖延迟。单次注射会延迟血凝素的产生，并且当从免疫前3天至抗血清采集前一天每天给予该酶时，血凝素的产生会受到抑制。这种剂型的L-天冬酰胺酶既能降低总抗体的产生，又能显著延长2-巯基乙醇敏感抗体的产生。L-天冬酰胺酶治疗的免疫抑制作用较弱，所研究的动物均未出现免疫反应的完全抑制。有人提出，当与另一种具有独立作用机制的药物联合使用时，天冬酰胺酶在预防原发性免疫发展方面将最为有效。
