Fink J S, Smith G P
Pharmacol Biochem Behav. 1979 Jul;11(1):23-30. doi: 10.1016/0091-3057(79)90292-2.
6-Hydroxydopamine (6-OHDA) injections into the anteromedial caudate nucleus (AMCN) produced severe loss of dopamine (DA) fibers in this region of the caudate. After a low dose of d'amphetamine (1.5 mg/kg), AMCN 6-OHDA rats made fewer traverses of the length of the activity cage than control rats. In contrast, AMCN 6-OHDA rats interrupted a photocell bema that passed across the middle of the long axis of the activity cage as often as control rats. 6-OHDA injections into the nucleus accumbens (NAc) produced severe loss of DA fibers in NAc without significantly damaging the adjacent anteromedial caudate or olfactory tubercle. After d-amphetamine (1.5 mg/kg), NAc 6-OHDA rats interrupted the photocell beam and traversed the length of the activity cage as frequently as control rats. We conclude that the DA innervation to the anteromedial caudate, but not to the nucleus accumbens, is necessary for that part of the normal locomotor response to a low dose of d'amphetamine that is required for the performance of long traverses of an activity cage.
向尾状核前内侧（AMCN）注射6-羟基多巴胺（6-OHDA）会导致该区域的多巴胺（DA）纤维严重损失。给予低剂量的右旋苯丙胺（1.5毫克/千克）后，接受AMCN 6-OHDA注射的大鼠在活动笼中穿越的次数比对照大鼠少。相比之下，接受AMCN 6-OHDA注射的大鼠中断穿过活动笼长轴中部的光电管横梁的次数与对照大鼠一样多。向伏隔核（NAc）注射6-OHDA会导致NAc中的DA纤维严重损失，而不会显著损害相邻的尾状核前内侧或嗅结节。给予右旋苯丙胺（1.5毫克/千克）后，接受NAc 6-OHDA注射的大鼠中断光电管光束并穿越活动笼长度的频率与对照大鼠一样高。我们得出结论，对于在活动笼中进行长距离穿越所需要的对低剂量右旋苯丙胺的正常运动反应的那部分而言，尾状核前内侧而非伏隔核的多巴胺神经支配是必需的。
