Whishaw I Q, Mittleman G
Department of Psychology, University of Lethbridge, Alberta, Canada.
Behav Neural Biol. 1991 May;55(3):289-306. doi: 10.1016/0163-1047(91)90633-2.
The experiments examined amphetamine-induced locomotion and stereotyped behavior in hippocampal-ablated and control rats for 30 days following surgery. Locomotor counts, stereotypy ratings, and locomotor-time profiles showed that d-amphetamine sulfate produced a selective enhancement of locomotion (cage crosses) at the expense of stereotyped behavior in hippocampal rats relative to normal control rats. This enhancement emerged over the first 2 weeks postsurgery. To examine the role of the striatum in this amphetamine-induced effect, combined hippocampal damage and 6-hydroxydopamine-induced damage of the nucleus accumbens or caudate-putamen were used. These results suggested that amphetamine-enhanced locomotion of hippocampal rats is dependent upon the integrity of the nucleus accumbens and may reflect a change of nucleus accumbens activity relative to caudate-putamen activity. Together these findings suggest that the hippocampus may participate in the control of locomotion by projections that modulate the activity of the nucleus accumbens.
实验研究了海马切除大鼠和对照大鼠在手术后30天内苯丙胺诱导的运动和刻板行为。运动计数、刻板行为评分和运动时间曲线表明，相对于正常对照大鼠，硫酸右旋苯丙胺使海马大鼠的运动（穿越笼子次数）选择性增强，代价是刻板行为减少。这种增强在手术后的前两周出现。为了研究纹状体在这种苯丙胺诱导效应中的作用，采用了联合海马损伤和6-羟基多巴胺诱导的伏隔核或尾状核-壳核损伤。这些结果表明，海马大鼠中苯丙胺增强的运动依赖于伏隔核的完整性，并且可能反映了伏隔核活动相对于尾状核-壳核活动的变化。这些发现共同表明，海马体可能通过调节伏隔核活动的投射参与运动控制。
