Calvo R, Carlos R, Erill S
Pharmacology. 1979;18(6):294-8. doi: 10.1159/000137268.
No hydrolysis of etomidate in plasma in vitro was detected in samples from man, horse, cow, sheep, guinea pig or white rabbit. Brown rabbits showed a moderate degree of hydrolysis and it was marked in plasma from Wistar rats. In this species, a single enzyme, an alliesterase, participated in the hydrolysis in plasma. Etomidate did not interfere with the hydrolysis of procaine by plasma pseudocholinesterase in man.
在人、马、牛、羊、豚鼠或白兔的样本中，未检测到依托咪酯在体外血浆中的水解情况。棕色兔显示出中等程度的水解，而在Wistar大鼠的血浆中水解明显。在该物种中，一种单一的酶，即一种烯丙酯酶，参与了血浆中的水解过程。依托咪酯不干扰人血浆假性胆碱酯酶对普鲁卡因的水解。
