Howard A N, Hyams D E
Br Med J. 1971 Jul 3;3(5765):25-7. doi: 10.1136/bmj.3.5765.25.
A comparison was made of the effect of DEAE (diethylaminoethyl) Sephadex (an anion exchange resin) and cholestyramine (Questran) with and without the addition of clofibrate in normal and hypercholesterolaemic patients. DEAE Sephadex (12-15 g/day) alone appeared to be as effective as cholestyramine in lowering the plasma cholesterol by 12-15%. Clofibrate acted synergistically with DEAE Sephadex and increased the activity of the latter by over twofold. This combination proved superior to that of clofibrate and cholestyramine and has the greatest potential use in the treatment of type II pattern hyperlipoproteinaemia.
对正常和高胆固醇血症患者，比较了二乙氨基乙基葡聚糖（DEAE，一种阴离子交换树脂）和消胆胺（考来烯胺）在添加和不添加氯贝丁酯情况下的效果。单独使用DEAE葡聚糖（12 - 15克/天）在降低血浆胆固醇方面似乎与消胆胺一样有效，可降低12 - 15%。氯贝丁酯与DEAE葡聚糖协同作用，使后者的活性提高了两倍多。这种组合被证明优于氯贝丁酯和消胆胺的组合，在治疗II型高脂蛋白血症方面具有最大的潜在应用价值。
